ArticleJournal of cell science2010
Regulated increase in folding capacity prevents unfolded protein stress in the ER.
Article in Journal of cell science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Monogenic diabetes: the role of mitochondrial dysfunction and endoplasmic reticulum stress.Frontiers in clinical diabetes and healthcare · 2025Review
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism.Endocrinology · 2023Article
- Unfolded Protein Response Is Activated by Aurora Kinase A in Esophageal Adenocarcinoma.Cancers · 2022Article
- CREB3L1 and CREB3L2 control Golgi remodelling during decidualization of endometrial stromal cells.Frontiers in cell and developmental biology · 2022Article
- Type I interferons and endoplasmic reticulum stress in health and disease.International review of cell and molecular biology · 2020Review
- Characterization of CNPY5 and its family members.Protein science : a publication of the Protein Society · 2019Article
- CREB3L1-mediated functional and structural adaptation of the secretory pathway in hormone-stimulated thyroid cells.Journal of cell science · 2017Article
- Endoplasmic Reticulum (ER) Stress and Endocrine Disorders.International journal of molecular sciences · 2017Review
- STAT3 and STAT6 Signaling Pathways Synergize to Promote Cathepsin Secretion from Macrophages via IRE1α Activation.Cell reports · 2016Article
- Endoplasmic Reticulum Stress May Play a Pivotal Role in Lipid Metabolic Disorders in a Novel Mouse Model of Subclinical Hypothyroidism.Scientific reports · 2016Article
- Enhancing antibody folding and secretion by tailoring the Saccharomyces cerevisiae endoplasmic reticulum.Microbial cell factories · 2016Article
- Ire1 supports normal ER differentiation in developing Drosophila photoreceptors.Journal of cell science · 2016Article
- Thyroglobulin From Molecular and Cellular Biology to Clinical Endocrinology.Endocrine reviews · 2016Review
- Article
- Adipocyte spliced form of X-box-binding protein 1 promotes adiponectin multimerization and systemic glucose homeostasis.Diabetes · 2014Article
- Mutation in osteoactivin decreases bone formation in vivo and osteoblast differentiation in vitro.The American journal of pathology · 2014Article
- Stressed out about obesity: IRE1α-XBP1 in metabolic disorders.Trends in endocrinology and metabolism: TEM · 2011Review
- Protein folding and quality control in the endoplasmic reticulum: Recent lessons from yeast and mammalian cell systems.Current opinion in cell biology · 2011Review
- A model of threshold behavior reveals rescue mechanisms of bystander proteins in conformational diseases.Biophysical journal · 2011Article
- Regulation of basal cellular physiology by the homeostatic unfolded protein response.The Journal of cell biology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
Abstract
Stimulation of thyrocytes with thyroid stimulating hormone (TSH) leads to a morphological change and a massive increase in thyroglobulin (Tg) production. Although Tg is a demanding client of the endoplasmic reticulum (ER), its increase did not result in significant accumulation of unfolded protein in the ER. Instead, ER chaperones and folding enzymes reached maximum synthesis rates immediately after TSH stimulation, before significant upregulation of Tg synthesis. The resulting increase in folding capacity before client protein production prevented cellular unfolded-protein stress, confirmed by the silence of the most conserved branch of the unfolded protein response. Thyrocytes set an example of physiological adaptation of cells to a future potentially stress-causing situation, which suggests a general strategy for both non-secretory and specialized secretory cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.