Trial reportRheumatology (Oxford, England)2010
Tendon friction rubs in early diffuse systemic sclerosis: prevalence, characteristics and longitudinal changes in a randomized controlled trial.
Trial report in Rheumatology (Oxford, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Assessment of skin involvement in systemic sclerosis.Rheumatology (Oxford, England) · 2017Pooled it
- [S2k guidelines on diagnostics and treatment of systemic sclerosis : Full version].Zeitschrift fur Rheumatologie · 2025Review
- Sclerodermic hand: a retrospective study on the role of ultrasonography in the detection of subclinical joint involvement.Clinical rheumatology · 2023Article
- Considerations for Hand Surgery in Patients With Scleroderma.Hand (New York, N.Y.) · 2023Review
- Musculoskeletal ultrasound of the shoulder in systemic sclerosis.Journal of scleroderma and related disorders · 2022Article
- Skin involvement in early diffuse cutaneous systemic sclerosis: an unmet clinical need.Nature reviews. Rheumatology · 2022Review
- ACE inhibitors in SSc patients display a risk factor for scleroderma renal crisis-a EUSTAR analysis.Arthritis research & therapy · 2020Article
- Serum YKL-40 and IL-6 levels correlate with ultrasound findings of articular and periarticular involvement in patients with systemic sclerosis.Rheumatology international · 2019Article
- Minimal Clinically Important Differences for the Modified Rodnan Skin Score: Results from the Scleroderma Lung Studies (SLS-I and SLS-II).Arthritis research & therapy · 2019Article
- Reliability and Validity of the Tender and Swollen Joint Counts and the Modified Rodnan Skin Score in Early Diffuse Cutaneous Systemic Sclerosis: Analysis from the Prospective Registry of Early Systemic Sclerosis Cohort.The Journal of rheumatology · 2017Article
- Hand Impairment in Systemic Sclerosis: Various Manifestations and Currently Available Treatment.Current treatment options in rheumatology · 2016Article
- Management of Musculoskeletal Involvement in Systemic Sclerosis.Current treatment options in rheumatology · 2016Article
- Management of Widespread Skin Thickening in Diffuse Systemic Sclerosis.Current treatment options in rheumatology · 2016Article
- Treatment of Rapidly Progressive Systemic Sclerosis: Current and Futures Perspectives.Expert opinion on orphan drugs · 2016Article
- Article
- Correlates and responsiveness to change of measures of skin and musculoskeletal disease in early diffuse systemic sclerosis.Arthritis care & research · 2014Observational
- Significance of palpable tendon friction rubs in early diffuse cutaneous systemic sclerosis.Arthritis care & research · 2013Article
- Magnetic resonance imaging findings in patients with systemic scleroderma and musculoskeletal symptoms.European radiology · 2013Article
- Gender and ethnicity differences in patients with diffuse systemic sclerosis--analysis from three large randomized clinical trials.Rheumatology (Oxford, England) · 2011Article
- Diffuse palpable tendon friction rubs in a patient with seronegative erosive polyarthritis.Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases · 2010Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectivesTo characterize the baseline tendon friction rubs (TFRs) in early dcSSc and to evaluate the association of change in TFR over 6 and 12 months with changes in modified Rodnan skin score (MRSS) and HAQ-Disability Index (HAQ-DI) over 12 and 24 months, respectively.
methodsWe analysed data from the d-Pen study, a 2-year study in early dcSSc (< or =18 months from first non-Raynaud's symptom). TFR was scored as present/absent at seven anatomical sites at baseline and every 6 months thereafter. Multivariable linear regression models assessed associations between TFR and change in MRSS, and change in the HAQ-DI, over 12 and 24 months, respectively. Covariates included baseline TFR, change in the TFR over 6 and 12 months, age, sex, duration of SSc, MRSS, and tender joint count and swollen joint count (SJC).
resultsForty-nine (37%) of 134 patients had TFR at baseline, 50% had resolution of their TFR, whereas 21% developed new TFRs. Patients with baseline TFRs were likely to be Caucasian (86 vs 58%) and had a higher HAQ-DI score (P = 0.008). In regression analyses, change in TFR (P = 0.04) and baseline MRSS (P = 0.03) predicted change in MRSS over a 12-month period (Model R(2 )= 0.14). For the HAQ-DI model, independent predictors were change in TFR at 6 months (P = 0.008) and baseline SJC (P = 0.04, Model R(2 )= 0.19). Results were similar for 24-month models.
conclusionsWe document the presence of TFR very early in the course of dcSSc. Changes in TFR over 6 and 12 months predict changes in MRSS and HAQ-DI over 12 and 24 months, respectively.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.