ReviewAutoimmunity reviews2010
Pathways: Strategies for susceptibility genes in SLE.
Review in Autoimmunity reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Evaluation of genetic association between an ITGAM non-synonymous SNP (rs1143679) and multiple autoimmune diseases.Autoimmunity reviews · 2012Pooled it
- Genetic Insights into Circulating Complement Proteins in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Potential Inflammatory Subgroup.International journal of molecular sciences · 2026Article
- Lupus Nephritis: Current Perspectives and Moving Forward.Journal of inflammation research · 2022Review
- Upregulation of FcγRIIB by resveratrol via NF-κB activation reduces B-cell numbers and ameliorates lupus.Experimental & molecular medicine · 2017Article
- Genetics of Lupus Nephritis: Clinical Implications.Seminars in nephrology · 2015Review
- Decreased ITGAM and FcγRIIIA mRNA expression levels in peripheral blood mononuclear cells from patients with systemic lupus erythematosus.Clinical and experimental medicine · 2014Article
- Clinical perspectives on lupus genetics: advances and opportunities.Rheumatic diseases clinics of North America · 2014Review
- Association study of CRP gene in systemic sclerosis in European Caucasian population.Rheumatology international · 2014Article
- Evaluation of SLE Susceptibility Genes in Malaysians.Autoimmune diseases · 2014Article
- Multiple lupus-associated ITGAM variants alter Mac-1 functions on neutrophils.Arthritis and rheumatism · 2013Article
- A study on anti-mannose binding lectin (anti-MBL) antibodies and serum MBL levels in Indian systemic lupus erythematosus patients.Rheumatology international · 2013Article
- A study on anti-mannose binding lectin (anti-MBL) antibodies and serum MBL levels in Indian systemic lupus erythematosus patients.Rheumatology international · 2013Article
- Age-related differences in the clinical characteristics of systemic lupus erythematosus in children.Rheumatology international · 2013Article
- Anti-C1q antibodies and their association with complement components in Indian systemic lupus erythematosus patients.Indian journal of nephrology · 2012Article
- Deletion of Syk in neutrophils prevents immune complex arthritis.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- To B or not to B: role of B cells in pathogenesis of arthritis in HLA transgenic mice.Journal of autoimmunity · 2011Review
- A systemic lupus erythematosus-associated R77H substitution in the CD11b chain of the Mac-1 integrin compromises leukocyte adhesion and phagocytosis.The Journal of biological chemistry · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Systemic lupus erythematosus (SLE) is a complex autoimmune disorder marked by an inappropriate immune response to nuclear antigens. Recent whole genome association and more focused studies have revealed numerous genes implicated in this disease process, including ITGAM, Fc gamma receptors, complement components, C-reactive protein, and others. One common feature of these molecules is their involvement in the immune opsonin pathway and in phagocytic clearing of nuclear antigens and apoptotic debris, which provide excessive exposure of lupus-related antigens to immune cells. Analysis of gene-gene interactions in the opsonin pathway and its relationship to SLE may provide a system-based approach to identify additional candidate genes associated with disease able to account for a larger part of lupus susceptibility.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.