ArticleExperimental neurology2010
The conditioning lesion effect on sympathetic neurite outgrowth is dependent on gp130 cytokines.
Article in Experimental neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- An In Vitro Model for Conditioning Lesion Effect.Cellular and molecular neurobiology · 2019Article
- Molecular and cellular identification of the immune response in peripheral ganglia following nerve injury.Journal of neuroinflammation · 2018Article
- Determinants of Axon Growth, Plasticity, and Regeneration in the Context of Spinal Cord Injury.The American journal of pathology · 2018Review
- Injury-induced gp130 cytokine signaling in peripheral ganglia is reduced in diabetes mellitus.Experimental neurology · 2017Article
- Overexpression of the monocyte chemokine CCL2 in dorsal root ganglion neurons causes a conditioning-like increase in neurite outgrowth and does so via a STAT3 dependent mechanism.Experimental neurology · 2016Article
- The neuroimmunology of degeneration and regeneration in the peripheral nervous system.Neuroscience · 2015Review
- Peripheral nerve regeneration and NGF-dependent neurite outgrowth of adult sensory neurons converge on STAT3 phosphorylation downstream of neuropoietic cytokine receptor gp130.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Signaling regulations of neuronal regenerative ability.Current opinion in neurobiology · 2014Review
- A critical role for macrophages near axotomized neuronal cell bodies in stimulating nerve regeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- STAT3 integrates cytokine and neurotrophin signals to promote sympathetic axon regeneration.Molecular and cellular neurosciences · 2013Article
- Developmental changes in the responsiveness of rat spiral ganglion neurons to neurotrophic factors in dissociated culture: differential responses for survival, neuritogenesis and neuronal morphology.Cell and tissue research · 2013Article
- Diet-induced obesity severely impairs myelinated aortic baroreceptor reflex responses.American journal of physiology. Heart and circulatory physiology · 2012Article
- Interleukin-17A increases neurite outgrowth from adult postganglionic sympathetic neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Activating transcription factor 3 and the nervous system.Frontiers in molecular neuroscience · 2012Article
- Role of transcription factors in peripheral nerve regeneration.Frontiers in molecular neuroscience · 2012Article
- Cardiac ischemia-reperfusion regulates sympathetic neuropeptide expression through gp130-dependent and independent mechanisms.Neuropeptides · 2011Article
- gp130 cytokines are positive signals triggering changes in gene expression and axon outgrowth in peripheral neurons following injury.Frontiers in molecular neuroscience · 2011Article
- Extrinsic and intrinsic determinants of nerve regeneration.Journal of tissue engineering · 2011Article
- Retinoic acid signaling in axonal regeneration.Frontiers in molecular neuroscience · 2011Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Sympathetic neurons, like sensory neurons, increase neurite outgrowth after a conditioning lesion. Studies in leukemia inhibitory factor (LIF) knockout animals showed that the conditioning lesion effect in sensory neurons is dependent in part on this cytokine; however, similar studies on sympathetic neurons revealed no such effect. Comparable studies with sensory neurons taken from mice lacking the related cytokine interleukin-6 (IL-6) have yielded conflicting results. LIF and IL-6 belong to a family of cytokines known as the gp130 family because they act on receptors containing the subunit gp130. In sympathetic ganglia, axotomy leads to increases in mRNA for four of these cytokines (LIF, IL-6, IL-11, and oncostatin M). To test the role of this family of cytokines as a whole in the conditioning lesion response in sympathetic neurons, mice in which gp130 was selectively eliminated in noradrenergic neurons were studied. The postganglionic axons of the SCG were transected, and 7days later the ganglia were removed and neurite outgrowth was measured in explant and dissociated cell cultures. In both systems, neurons from wild type animals showed enhanced growth after a conditioning lesion. In contrast, no enhancement occurred in neurons from mutant animals. This lack of stimulation of outgrowth occurred despite an increase in expression of activating transcription factor 3 (ATF3) in the mutant mice. These studies demonstrate that stimulation of enhanced growth of sympathetic neurons after a conditioning lesion is dependent on gp130 cytokine signaling and is blocked in the absence of signaling by these cytokines in spite of an increase in ATF3.
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