ArticleNeuroscience2010
Gene expression profiling following short-term and long-term morphine exposure in mice uncovers genes involved in food intake.
Article in Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Functional genomic mechanisms of opioid action and opioid use disorder: a systematic review of animal models and human studies.Molecular psychiatry · 2023Pooled it
- Peroxisome, neuropeptide, and inflammation signaling pathways uniquely impacted by opioid exposure in the hypothalamus of males and females.Molecular and cellular neurosciences · 2025Article
- Investigating the Effect of Enterally Administered Capromorelin on Body Weight in Mice (Mus musculus).Comparative medicine · 2024Article
- Regulation of body weight and food intake by AGRP neurons during opioid dependence and abstinence in mice.Frontiers in neural circuits · 2022Article
- Genetic variation regulates opioid-induced respiratory depression in mice.Scientific reports · 2020Article
- CART Peptides and Drugs of Abuse: A Review of Recent Progress.Journal of drug and alcohol research · 2016Article
- Effect of the co-administration of glucose with morphine on glucoregulatory hormones and causing of diabetes mellitus in rats.Advanced biomedical research · 2016Article
- Article
- Alterations in phosphorylated CREB expression in different brain regions following short- and long-term morphine exposure: relationship to food intake.Journal of obesity · 2013Article
- Article
- Morphine potentiates neuropathogenesis of SIV infection in rhesus macaques.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2011Article
- Effects of neonatal stress and morphine on murine hippocampal gene expression.Pediatric research · 2011Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Addictive drugs including opioids activate signal transduction pathways that regulate gene expression in the brain. However, changes in CNS gene expression following morphine exposure are poorly understood. We determined changes in gene expression following short- and long-term morphine treatment in the hypothalamus and pituitary using genome-wide DNA microarray analysis and confirmed those alterations in gene expression by real-time reverse transcriptase polymerase chain reaction (RT-PCR) analysis. In the hypothalamus, short-term morphine administration up-regulated (at least twofold) 39 genes and down-regulated six genes. Long-term morphine treatment up-regulated 35 genes and down-regulated 51 genes. In the pituitary, short-term morphine administration up-regulated 110 genes and down-regulated 29 genes. Long-term morphine treatment up-regulated 85 genes and down-regulated 37 pituitary genes. Microarray analysis uncovered several genes involved in food intake (neuropeptide Y, agouti-related protein, and cocaine and amphetamine-regulated transcript) whose expression was strongly altered by morphine exposure in either the hypothalamus or pituitary. Subsequent RT-PCR analysis confirmed similar regulation in expression of these genes in the hypothalamus and pituitary. Finally, we found functional correlation between morphine-induced alterations in food intake and regulation of genes involved in this process. Changes in genes related to food intake may uncover new pathways related to some of the physiological effects of opioids.
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Registered trials
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