ReviewMolecular and cellular endocrinology2010
Genetic determinants of pubertal timing in the general population.
Review in Molecular and cellular endocrinology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 120 citations in OpenAlex.
- Spatiotemporal Patterns of Age at Menarche or Spermarche in Chinese Children and Adolescents and Socioeconomic and Environmental Determinants: Findings from a Series of Nation-Wide Surveys, 1995 to 2019.Environment & health (Washington, D.C.) · 2026Article
- Impact of conflict-induced stress on the length of craniofacial growth.Scientific reports · 2025Article
- Prevalence of organic central precocious puberty in males: criteria for a high index of suspicion.Endocrine connections · 2025Article
- Time-varying associations of gestational and childhood triclosan with pubertal and adrenarchal outcomes in early adolescence.Environmental epidemiology (Philadelphia, Pa.) · 2024Article
- Interaction between Vitamin D homeostasis, gut microbiota, and central precocious puberty.Frontiers in endocrinology · 2024Review
- Transcriptome Sequencing-Based Mining of Genes Associated With Pubertal Initiation in Dolang Sheep.Frontiers in genetics · 2022Article
- Sexual maturation of HIV-infected and uninfected male children in Abakaliki, South-East, Nigeria: a cross-sectional study.The Pan African medical journal · 2022Article
- Gene Polymorphisms Associated with Central Precocious Puberty and Hormone Levels in Chinese Girls.International journal of endocrinology · 2022Article
- A review of the genetics and epigenetics of central precocious puberty.Frontiers in endocrinology · 2022Review
- Timing of Puberty and Late Pubertal Height in Saudi Schoolboys: Riyadh Puberty Study II.International journal of endocrinology · 2022Article
- Association between factors related to the pregnancy, neonatal period, and later complications (especially asthma) and menarcheal age in a sample of Lebanese girls.BMC women's health · 2020Article
- Body mass index growth trajectories, early pubertal maturation, and short stature.Pediatric research · 2020Article
- The analysis of endocrine disruptors in patients with central precocious puberty.BMC pediatrics · 2019Article
- The MakorineLife · 2019Article
- Interdisciplinary Work Is Essential for Research on Puberty: Complexity and Dynamism in Action.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2019Review
- A novel familial 9q31.2q32 microdeletion: Muscle cramping, somnolence, fatigue, sensorineural hearing loss, pubertal delay, and short stature.Clinical case reports · 2019Article
- Cloning and expression of lin-28 homolog B gene in the onset of puberty in Duolang sheep.Asian-Australasian journal of animal sciences · 2019Article
- MKRN3 Interacts With Several Proteins Implicated in Puberty Timing but Does Not InfluenceFrontiers in endocrinology · 2019Article
- SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression.Nature communications · 2018Article
- Delayed puberty versus hypogonadism: a challenge for the pediatrician.Annals of pediatric endocrinology & metabolism · 2018Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
Puberty is an important developmental stage during which reproductive capacity is attained. The timing of puberty varies greatly among healthy individuals in the general population and is influenced by both genetic and environmental factors. Although genetic variation is known to influence the normal spectrum of pubertal timing, the specific genes involved remain largely unknown. Genetic analyses have identified a number of genes responsible for rare disorders of pubertal timing such as hypogonadotropic hypogonadism and Kallmann syndrome. Recently, the first loci with common variation reproducibly associated with population variation in the timing of puberty were identified at 6q21 in or near LIN28B and at 9q31.2. However, these two loci explain only a small fraction of the genetic contribution to population variation in pubertal timing, suggesting the need to continue to consider other loci and other types of variants. Here we provide an update of the genes implicated in disorders of puberty, discuss genes and pathways that may be involved in the timing of normal puberty, and suggest additional avenues of investigation to identify genetic regulators of puberty in the general population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.