ArticleMolecular and biochemical parasitology2010
Proteomic study of activated Taenia solium oncospheres.
Article in Molecular and biochemical parasitology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- An Integrated Approach of Proteomic, Cheminformatic, and In Vitro Drug Screening to Identify Potential Therapeutic Targets ofACS omega · 2025Article
- Characterization of antigenic proteins of the Taenia solium postoncospheral form.Molecular and biochemical parasitology · 2024Article
- Mass Spectrometry Identifies Taenia solium Proteins in Sera of Patients With and Without Parenchymal Neurocysticercosis.Parasite immunology · 2024Article
- Taenia solium cysticerci's extracellular vesicles Attenuate the AKT/mTORC1 pathway for Alleviating DSS-induced colitis in a murine model.Journal of extracellular vesicles · 2024Article
- Differential Protein Expression ofPathogens (Basel, Switzerland) · 2023Article
- Proteomic analysis ofFrontiers in veterinary science · 2022Article
- Trichuris trichiura egg extract proteome reveals potential diagnostic targets and immunomodulators.PLoS neglected tropical diseases · 2021Article
- Immunoproteomic Analysis ofPathogens (Basel, Switzerland) · 2021Article
- iTRAQ-based comparative proteomic analysis in different developmental stages of Echinococcus granulosus.Parasite (Paris, France) · 2021Article
- Proteomic Insights into the Biology of the Most Important Foodborne Parasites in Europe.Foods (Basel, Switzerland) · 2020Review
- Taenia solium Cysticercosis and Its Impact in Neurological Disease.Clinical microbiology reviews · 2020Review
- Proteomics Analysis ofFrontiers in veterinary science · 2020Article
- Molecular characterisation and expression analysis of two heat-shock proteins in Taenia multiceps.Parasites & vectors · 2019Article
- A gel-free proteomic analysis of Taenia solium and Taenia crassiceps cysticerci vesicular extracts.Parasitology research · 2018Article
- Trichinella britovi muscle larvae and adult worms: stage-specific and common antigens detected by two-dimensional gel electrophoresis-based immunoblotting.Parasites & vectors · 2018Article
- Immunoproteomics and Surfaceomics of the Adult TapewormFrontiers in immunology · 2018Article
- Identification of immunogenic proteins of the cysticercoid of Hymenolepis diminuta.Parasites & vectors · 2017Article
- "Omic" investigations of protozoa and worms for a deeper understanding of the human gut "parasitome".PLoS neglected tropical diseases · 2017Review
- Quantitative multiplexed proteomics of Taenia solium cysts obtained from the skeletal muscle and central nervous system of pigs.PLoS neglected tropical diseases · 2017Article
- Comparative Proteomic Analysis ofFrontiers in microbiology · 2017Article
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Authors and funding
12 authors.
Funding
Abstract
Taenia solium cysticerci are a major cause of human seizures and epilepsy in the world. In the gastrointestinal tract of infected individuals, taeniid eggs release the oncospheres, which are then activated by intestinal stimuli, getting ready to penetrate the gut wall and reach distant locations where they transform in cysticerci. Information about oncospheral molecules is scarce, and elucidation of the oncosphere proteome could help understanding the host-parasite relationship during the first steps of infection. In this study, using liquid chromatography and tandem mass spectrometry (LC-MS/MS) analysis, we could identify a set of oncospheral proteins involved in adhesion, protein folding, detoxification and proteolysis, among others. In addition, we have characterized one of the identified molecules, the parasite 14-3-3, by immunoblot and immunolocalization. The identification of these oncospheral proteins represents the first step to elucidate their specific roles in the biology of the host-parasite relationship.
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