ReviewFrontiers in neuroendocrinology2010
Long-term impact of neonatal injury in male and female rats: Sex differences, mechanisms and clinical implications.
Review in Frontiers in neuroendocrinology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Sex differences in the transition to chronic pain.The Journal of clinical investigation · 2025Review
- Role of Glutamatergic Projections from Lateral Habenula to Ventral Tegmental Area in Inflammatory Pain-Related Spatial Working Memory Deficits.Biomedicines · 2023Article
- Article
- Early life nociceptive stimulus and fentanyl exposure increase hippocampal neurogenesis and anxiety but do not affect spatial learning and memory.Frontiers in neuroscience · 2022Article
- Interleukin-1 receptor antagonist ameliorates the pain hypersensitivity, spinal inflammation and oxidative stress induced by systemic lipopolysaccharide in neonatal rats.Neurochemistry international · 2020Article
- The development of pain circuits and unique effects of neonatal injury.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
- Systemic Lipopolysaccharide-Induced Pain Sensitivity and Spinal Inflammation Were Reduced by Minocycline in Neonatal Rats.International journal of molecular sciences · 2018Article
- Opioid analgesia and the somatosensory memory of neonatal surgical injury in the adult rat.British journal of anaesthesia · 2018Article
- Tail Docking of Canine Puppies: Reassessment of the Tail's Role in Communication, the Acute Pain Caused by Docking and Interpretation of Behavioural Responses.Animals : an open access journal from MDPI · 2018Article
- Early life vincristine exposure evokes mechanical pain hypersensitivity in the developing rat.Pain · 2017Article
- Ethnic Differences in the Effects of Naloxone on Sustained Evoked Pain: A Preliminary Study.Diversity and equality in health and care · 2017Article
- Neonatal repetitive pain in rats leads to impaired spatial learning and dysregulated hypothalamic-pituitary-adrenal axis function in later life.Scientific reports · 2016Article
- Exposure to Early Life Pain: Long Term Consequences and Contributing Mechanisms.Current opinion in behavioral sciences · 2016Article
- The long-term impact of early life pain on adult responses to anxiety and stress: Historical perspectives and empirical evidence.Experimental neurology · 2016Review
- Invasive procedures in preterm children: brain and cognitive development at school age.Pediatrics · 2014Article
- Use of an eight-arm radial water maze to assess working and reference memory following neonatal brain injury.Journal of visualized experiments : JoVE · 2013Article
- Neonatal pain-related stress and NFKBIA genotype are associated with altered cortisol levels in preterm boys at school age.PloS one · 2013Article
- Priming of adult pain responses by neonatal pain experience: maintenance by central neuroimmune activity.Brain : a journal of neurology · 2012Article
- Sexual dimorphism in endothelin-1 induced mechanical hyperalgesia in the rat.Experimental neurology · 2012Article
- Early life adversity as a risk factor for fibromyalgia in later life.Pain research and treatment · 2012Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Over the last several decades, the relative contribution of early life events to individual disease susceptibility has been explored extensively. Only fairly recently, however, has it become evident that abnormal or excessive nociceptive activity experienced during the perinatal period may permanently alter the normal development of the CNS and influence future responses to somatosensory input. Given the significant rise in the number of premature infants receiving high-technology intensive care over the last 20 years, ex-preterm neonates may be exceedingly vulnerable to the long-term effects of repeated invasive interventions. The present review summarizes available clinical and laboratory findings on the lasting impact of exposure to noxious stimulation during early development, with a focus on the structural and functional alterations in nociceptive circuits, and its sexually dimorphic impact.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.