ArticleJournal of diabetes science and technology2009
Plasma-generating glucose monitor accuracy demonstrated in an animal model.
Article in Journal of diabetes science and technology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Evaluation of a continuous blood glucose monitoring system using central venous microdialysis.Journal of diabetes science and technology · 2012Trial
- A stepwise approach toward closed-loop blood glucose control for intensive care unit patients: results from a feasibility study in type 1 diabetic subjects using vascular microdialysis with infrared spectrometry and a model predictive control algorithm.Journal of diabetes science and technology · 2011Trial
- Manual versus Automated moNitoring Accuracy of GlucosE II (MANAGE II).Critical care (London, England) · 2016Article
- Accuracy and limitations of continuous glucose monitoring using spectroscopy in critically ill patients.Annals of intensive care · 2014Article
- Glucose measurement of intensive care unit patient plasma samples using a fixed-wavelength mid-infrared spectroscopy system.Journal of diabetes science and technology · 2012Article
- Intensive insulin therapy in critically ill hospitalized patients: making it safe and effective.Journal of diabetes science and technology · 2011Review
- Automated near-continuous glucose monitoring measured in plasma using mid-infrared spectroscopy.Journal of diabetes science and technology · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionFour randomized controlled trials have compared mortality and morbidity of tight glycemic control versus conventional glucose for intensive care unit (ICU) patients. Two trials showed a positive outcome. However, one single-center trial and a large multicenter trial had negative results. The positive trials used accurate portable lab analyzers. The negative trial allowed the use of meters. The portable analyzer measures in filtered plasma, minimizing the interference effects. OptiScan Biomedical Corporation is developing a continuous glucose monitor using centrifuged plasma and mid-infrared spectroscopy for use in ICU medicine. The OptiScanner draws approximately 0.1 ml of blood every 15 min and creates a centrifuged plasma sample. Internal quality control minimizes sample preparation error. Interference adjustment using this technique has been presented at the Society of Critical Care Medicine in separate studies since 2006.
methodA good laboratory practice study was conducted on three Yorkshire pigs using a central venous catheter over 6 h while performing a glucose challenge. Matching Yellow Springs Instrument glucose readings were obtained.
resultsSome 95.7% of the predicted values were in the Clarke Error Grid A zone and 4.3% in the B zone. Of those in the B zone, all were within 3.3% of the A zone boundaries. The coefficient of determination (R(2)) was 0.993. The coefficient of variance was 5.02%. Animal necropsy and blood panels demonstrated safety.
conclusionThe OptiScanner investigational device performed safely and accurately in an animal model. Human studies using the device will begin soon.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.