ReviewJournal of diabetes science and technology2009
Reducing glycemic variability in intensive care unit patients: a new therapeutic target?
Review in Journal of diabetes science and technology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Short-term glycemic variability and the risk of adverse ICU outcomes in critically ill patients: a systematic review and meta-analysis.Frontiers in nutrition · 2026Pooled it
- Evaluation of a continuous blood glucose monitoring system using central venous microdialysis.Journal of diabetes science and technology · 2012Trial
- A Wearable, Dual Closed-loop Insulin Delivery System for Precision Diabetes Management.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Glycemic variability and mortality in oncologic intensive care units.Revista brasileira de enfermagem · 2023Article
- Estimating Enhanced Endogenous Glucose Production in Intensive Care Unit Patients with Severe Insulin Resistance.Journal of diabetes science and technology · 2022Article
- Acute glycemic variability and mortality of patients with acute stroke: a meta-analysis.Diabetology & metabolic syndrome · 2022Article
- Acute glycemic variability and risk of mortality in patients with sepsis: a meta-analysis.Diabetology & metabolic syndrome · 2022Article
- The prognostic role of hyperglycemia and glucose variability in covid-related acute respiratory distress Syndrome.Diabetes research and clinical practice · 2021Article
- Increased insulin resistance in intensive care: longitudinal retrospective analysis of glycaemic control patients in a New Zealand ICU.Therapeutic advances in endocrinology and metabolism · 2021Article
- Risk-Based Care: Let's Think Outside the Box.Frontiers in medicine · 2021Article
- Maximal Glycemic Difference, the Possible Strongest Glycemic Variability Parameter to Predict Mortality in ICU Patients.Critical care research and practice · 2020Article
- Association of multiple glycemic parameters at intensive care unit admission with mortality and clinical outcomes in critically ill patients.Scientific reports · 2019Article
- Impact of an inpatient multidisciplinary glucose control management program.Archives of endocrinology and metabolism · 2018Article
- Article
- Next-generation, personalised, model-based critical care medicine: a state-of-the art review of in silico virtual patient models, methods, and cohorts, and how to validation them.Biomedical engineering online · 2018Review
- Glucometrics and Insulinometrics.Current diabetes reports · 2017Review
- Continuous Glucose Monitoring in Patients Undergoing Extracorporeal Ventricular Assist Therapy.PloS one · 2016Article
- Perioperative Hyperglycemia and Glucose Variability in Gynecologic Laparotomies.Journal of diabetes science and technology · 2015Observational
- Evaluation of intravascular microdialysis for continuous blood glucose monitoring in hypoglycemia: an animal model.Journal of diabetes science and technology · 2014Article
- Hypoglycaemia in anesthesiology practice: Diagnostic, preventive, and management strategies.Saudi journal of anaesthesia · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute hyperglycemia is common in critically ill patients. Strict control of blood glucose (BG) concentration has been considered important because hyperglycemia is associated independently with increased intensive care unit mortality. After intensive insulin therapy was reported to reduce mortality in selected surgical critically ill patients, lowering of BG levels was recommended as a means of improving patient outcomes. However, a large multicenter multination study has found that intensive insulin therapy increased mortality significantly. A difference in variability of BG control may be one possible explanation why the effect of intensive insulin therapy varied from beneficial to harmful. Several studies have confirmed significant associations between variability of BG levels and patient outcomes. Decreasing the variability of the BG concentration may be an important dimension of glucose management. If reducing swings in the BG concentration is a major biologic mechanism behind the putative benefits of glucose control, it may not be necessary to pursue lower glucose levels with their attendant risk of hypoglycemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.