ArticleJournal of diabetes science and technology2009
In silico preclinical trials: methodology and engineering guide to closed-loop control in type 1 diabetes mellitus.
Article in Journal of diabetes science and technology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 80 citations in OpenAlex.
- Validating medical digital twins for clinical decision support: beyond predictive accuracy.JAMIA open · 2026Review
- Validation in diabetic rats of a fully automated insulin delivery system based on impulsive offset-free MPC control.PloS one · 2025Article
- Immune-evasive beta cells in type 1 diabetes: innovations in genetic engineering, biomaterials, and computational modeling.Frontiers in immunology · 2025Review
- Connecting Rodent and Human Pharmacokinetic Models for the Design and Translation of Glucose-Responsive Insulin.Diabetes · 2020Article
- Simulation Software for Assessment of Nonlinear and Adaptive Multivariable Control Algorithms: Glucose - Insulin Dynamics in Type 1 Diabetes.Computers & chemical engineering · 2019Article
- Translation Between Two Models; Application with Integrated Glucose Homeostasis Models.Pharmaceutical research · 2019Article
- Neural network-based model predictive control for type 1 diabetic rats on artificial pancreas system.Medical & biological engineering & computing · 2019Article
- Autoregressive Modeling of Drift and Random Error to Characterize a Continuous Intravascular Glucose Monitoring Sensor.Journal of diabetes science and technology · 2018Article
- Article
- Design and Evaluation of a Robust PID Controller for a Fully Implantable Artificial Pancreas.Industrial & engineering chemistry research · 2015Article
- Population-Specific Models of Glycemic Control in Intensive Care: Towards a Simulation-Based Methodology for Protocol Optimization.Proceedings of the ... American Control Conference. American Control Conference · 2015Article
- The mathematician's control toolbox for management of type 1 diabetes.Interface focus · 2014Review
- Automated control of an adaptive bihormonal, dual-sensor artificial pancreas and evaluation during inpatient studies.IEEE transactions on bio-medical engineering · 2014Article
- A computational proof of concept of a machine-intelligent artificial pancreas using Lyapunov stability and differential game theory.Journal of diabetes science and technology · 2014Article
- Closed-Loop Control Performance of the Hypoglycemia-Hyperglycemia Minimizer (HHM) System in a Feasibility Study.Journal of diabetes science and technology · 2014Article
- Treating type 1 diabetes: from strategies for insulin delivery to dual hormonal control.Minerva endocrinologica · 2013Review
- Model identification using stochastic differential equation grey-box models in diabetes.Journal of diabetes science and technology · 2013Article
- Challenges and Recent Progress in the Development of a Closed-loop Artificial Pancreas.Annual reviews in control · 2012Article
- Modular closed-loop control of diabetes.IEEE transactions on bio-medical engineering · 2012Article
- Closed-loop insulin delivery: from bench to clinical practice.Nature reviews. Endocrinology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This article sets forth guidelines for in silico (simulation-based) proof-of-concept testing of artificial pancreas control algorithms. The goal was to design a test procedure that can facilitate regulatory approval [e.g., Food and Drug Administration Investigational Device Exemption] for General Clinical Research Center experiments without preliminary testing on animals. The methodology is designed around a software package, based on a recent meal simulation model of the glucose-insulin system. Putting a premium on generality, this document starts by specifying a generic, rather abstract, meta-algorithm for control. The meta-algorithm has two main components: (1) patient assessment and tuning of control parameters, i.e., algorithmic processes for collection and processing patient data prior to closed-loop operation, and (2) controller warm-up and run-time operation, i.e., algorithmic processes for initializing controller states and managing blood glucose. The simulation-based testing methodology is designed to reveal the conceptual/mathematical operation of both main components, as applied to a large population of in silico patients with type 1 diabetes mellitus.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.