ReviewJournal of diabetes science and technology2009
Genetics factors contributing to type 2 diabetes across ethnicities.
Review in Journal of diabetes science and technology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Genetic predisposition of LEPR (rs1137101) gene polymorphism related to type 2 diabetes mellitus - a meta-analysis.Annals of medicine · 2023Pooled it
- Ethnicity-related differences in mitochondrial regulation by insulin stimulation in diabetes.Journal of cellular physiology · 2024Review
- The Need for Ethnoracial Equity in Artificial Intelligence for Diabetes Management: Review and Recommendations.Journal of medical Internet research · 2021Review
- Heredity of type 2 diabetes confers increased susceptibility to oxidative stress and inflammation.BMJ open diabetes research & care · 2020Article
- Analysis of Comprehensive Pharmacogenomic Profiling of VIP Variants Among the Genetically Isolated Chechen Subpopulation from Jordan.Pharmacogenomics and personalized medicine · 2020Article
- Evidence based review of type 2 diabetes prevention and management in low and middle income countries.World journal of diabetes · 2016Article
- Article
- Disparities in diabetes: the nexus of race, poverty, and place.American journal of public health · 2014Article
- Immigrant generation and diabetes risk among Mexican Americans: the Sacramento area Latino study on aging.American journal of public health · 2014Article
- Evidence of reduced β-cell function in Asian Indians with mild dysglycemia.Diabetes care · 2013Article
- Diabetes risk in older Mexican Americans: effects of language acculturation, generation and socioeconomic status.Journal of cross-cultural gerontology · 2013Article
- [Immigrant generation and diabetes risk among Mexican Americans: the Sacramento Area Latino Study on Aging].Revista panamericana de salud publica = Pan American journal of public health · 2013Article
- Immigrant generation and diabetes risk among Mexican Americans: the Sacramento Area Latino Study on Aging.American journal of public health · 2013Article
- Newborn size and body composition as predictors of insulin resistance and diabetes in the parents: Parthenon Birth Cohort Study, Mysore, India.Diabetes care · 2012Article
- Single nucleotide polymorphisms in JAZF1 and BCL11A gene are nominally associated with type 2 diabetes in African-American families from the GENNID study.Journal of human genetics · 2012Article
- Type 2 diabetes risk alleles demonstrate extreme directional differentiation among human populations, compared to other diseases.PLoS genetics · 2012Article
- Article
- The personalized medicine for diabetes meeting summary report.Journal of diabetes science and technology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Type 2 diabetes mellitus (T2DM) is among the many common diseases with a strong genetic component, but until recently, the variants causing this disease remained largely undiscovered. With the ability to interrogate most of the variation in the genome, the number of genetic variants has grown from 2 to 19 genes, many with multiple variants. An additional three genes are associated primarily with fasting glucose rather than T2DM. Despite the plethora of new markers, the individual effect is uniformly small, and the cumulative effect explains little of the genetic risk for T2DM. Furthermore, the success is largely restricted to European populations. Despite success in mapping genes in Asian populations, success in United States minorities, particularly African Americans, has been limited. The genetic findings highlight the role of the beta cell in diabetes pathogenesis, but much remains to be discovered before genetic prediction and individualized medicine can become a reality for this disease.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.