ArticleBMC microbiology2010
Transcriptional profiling reveals the expression of novel genes in response to various stimuli in the human dermatophyte Trichophyton rubrum.
Article in BMC microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 66 citations in OpenAlex.
- Epidemiology and Three-Month Recurrence of Tinea Infections in a Prison: A Cross-Sectional Study.Cureus · 2026Article
- Terbinafine Resistance inAntibiotics (Basel, Switzerland) · 2025Review
- Mechanisms of resistance against allylamine and azole antifungals in Trichophyton: A renewed call for innovative molecular diagnostics in susceptibility testing.PLoS pathogens · 2025Review
- Comparative analysis of whole genomes and transcriptomes ofEmerging microbes & infections · 2023Article
- Dermatophyte infection: from fungal pathogenicity to host immune responses.Frontiers in immunology · 2023Review
- A Dual-Plasmid-Based CRISPR/Cas9-Mediated Strategy Enables Targeted Editing of pH Regulatory GeneJournal of fungi (Basel, Switzerland) · 2022Article
- Secretory Proteases of the Human Skin Microbiome.Infection and immunity · 2022Article
- Relevance of Nutrient-Sensing in the Pathogenesis ofFrontiers in fungal biology · 2022Article
- New Reference Genes for qRT-PCR Analysis as a Potential Target for Identification ofPathogens (Basel, Switzerland) · 2021Article
- Whole genome sequences of two3 Biotech · 2021Article
- State-of-the-Art Dermatophyte Infections: Epidemiology Aspects, Pathophysiology, and Resistance Mechanisms.Journal of fungi (Basel, Switzerland) · 2021Review
- Saline stress affects the pH-dependent regulation of the transcription factor PacC in the dermatophyte Trichophyton interdigitale.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020Article
- Genes Encoding Proteolytic Enzymes Fungalysin and Subtilisin in Dermatophytes of Human and Animal Origin: A Comparative Study.Mycopathologia · 2020Article
- Reference genes for accurate evaluation of expression levels in Trichophyton interdigitale grown under different carbon sources, pH levels and phosphate levels.Scientific reports · 2019Article
- Dermatophyte Resistance to Antifungal Drugs: Mechanisms and Prospectus.Frontiers in microbiology · 2018Review
- Thigmo Responses: The Fungal Sense of Touch.Microbiology spectrum · 2017Review
- Pathogenesis of Dermatophytosis: Sensing the Host Tissue.Mycopathologia · 2017Review
- Photodynamic therapy as an antifungal treatment.Experimental and therapeutic medicine · 2016Article
- Heat Shock Proteins in Dermatophytes: Current Advances and Perspectives.Current genomics · 2016Article
- Transcription profile of Trichophyton rubrum conidia grown on keratin reveals the induction of an adhesin-like protein gene with a tandem repeat pattern.BMC genomics · 2016Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCutaneous mycoses are common human infections among healthy and immunocompromised hosts, and the anthropophilic fungus Trichophyton rubrum is the most prevalent microorganism isolated from such clinical cases worldwide. The aim of this study was to determine the transcriptional profile of T. rubrum exposed to various stimuli in order to obtain insights into the responses of this pathogen to different environmental challenges. Therefore, we generated an expressed sequence tag (EST) collection by constructing one cDNA library and nine suppression subtractive hybridization libraries.
resultsThe 1388 unigenes identified in this study were functionally classified based on the Munich Information Center for Protein Sequences (MIPS) categories. The identified proteins were involved in transcriptional regulation, cellular defense and stress, protein degradation, signaling, transport, and secretion, among other functions. Analysis of these unigenes revealed 575 T. rubrum sequences that had not been previously deposited in public databases.
conclusionIn this study, we identified novel T. rubrum genes that will be useful for ORF prediction in genome sequencing and facilitating functional genome analysis. Annotation of these expressed genes revealed metabolic adaptations of T. rubrum to carbon sources, ambient pH shifts, and various antifungal drugs used in medical practice. Furthermore, challenging T. rubrum with cytotoxic drugs and ambient pH shifts extended our understanding of the molecular events possibly involved in the infectious process and resistance to antifungal drugs.
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