Evidence map›Paper›PMID 20143945›Full record

ReviewFuture microbiology2010

Host-microbe interaction systems biology: lifecycle transcriptomics and comparative genomics.

Daniel E Sturdevant, Kimmo Virtaneva, Craig Martens, Daniel Bozinov, Olajumoke Ogundare, Nina Castro, Kishore Kanakabandi, Paul A Beare, Anders Omsland, Anders Ohmsland and 7 more

Erratum issuedOpen access · greenAbstract readReview
In one paragraph

Review in Future microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Multi-omic network signatures of disease.Frontiers in genetics · 2014
    Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

  • Erratum issued
    Ohmsland, Anders [corrected to Omsland, Anders]
5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Daniel E SturdevantGenomics Unit, Research Technologies Section, Research Technologies Branch, Rocky Mountain Laboratories, NIH, 904 South 4th Street, Hamilton, MT 59840, USA. dsturdevant@niaid.nih.gov
Kimmo Virtaneva
Craig Martens
Daniel Bozinov
Olajumoke Ogundare
Nina Castro
Kishore Kanakabandi
Paul A Beare
Anders Omsland
Anders Ohmsland
John H Carlson
Adam D Kennedy
Robert A Heinzen
Jean Celli
David E Greenberg
Frank R DeLeo
Stephen F Porcella
National Institutes of Health · USNational Institute of Allergy and Infectious Diseases · US

Funding

Infectious Diseases Research Technologies Core - RMLZICAI001052 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI CHERRY, JAMES · 2009 to 2025
$133.3M
Mechanisms of Staphylococcus aureus virulenceZIAAI001079 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI DELEO, FRANK · 2009 to 2025
$11.8M
Genetics of Coxiella burnetiiZIAAI000946 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HEINZEN, ROBERT A · 2009 to 2023
$8.9M
Intramural NIH HHS Z99 AI999999Intramural NIH HHS ZIC AI001052
6 · The paper itself

Abstract

The use of microarray and comparative genomic technologies for the analysis of host-pathogen interactions has led to a greater understanding of the biological systems involved in infectious disease processes. Transcriptome analysis of intracellular pathogens at single or multiple time points during infection offers insight into the pathogen intracellular lifecycle. Host-pathogen transcriptome analysis in vivo, over time, enables characterization of both the pathogen and the host during the dynamic, multicellular host response. Comparative genomics using hybridization microarray-based comparative whole-genome resequencing or de novo whole-genome sequencing can identify the genetic factors responsible for pathogen evolutionary divergence, emergence, reemergence or the genetic basis for different pathogenic phenotypes. Together, microarray and comparative genomic technologies will continue to advance our understanding of pathogen evolution and assist in combating human infectious disease.

Indexed as

Host-Pathogen InteractionsComparative Genomic HybridizationGene Expression ProfilingHumansMicroarray AnalysisSequence Analysis, DNASystems Biology

Identifiers

PMID20143945
PMCPMC2846718
OpenAlexW2039842069

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.