ReviewLymphatic research and biology2009
Lymphatics in human lymphatic filariasis: in vitro models of parasite-induced lymphatic remodeling.
Review in Lymphatic research and biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- Therapeutic and Formulation Advances of Ivermectin in Veterinary and Human Medicine.Pharmaceutics · 2025Review
- Current perspectives in the epidemiology and control of lymphatic filariasis.Clinical microbiology reviews · 2025Review
- The Role of Inflammation in Lymphedema: A Narrative Review of Pathogenesis and Opportunities for Therapeutic Intervention.International journal of molecular sciences · 2024Review
- Tetracyclines improve experimental lymphatic filariasis pathology by disrupting interleukin-4 receptor-mediated lymphangiogenesis.The Journal of clinical investigation · 2021Article
- Case Studies of Severe Microfilaremia in Four Dogs Naturally Infected WithFrontiers in veterinary science · 2020Article
- Angiogenic response in an in vitro model of dog microvascular endothelial cells stimulated with antigenic extracts from Dirofilaria immitis adult worms.Parasites & vectors · 2019Article
- Epidemiological screening and xenomonitoring for human lymphatic filariasis infection in select districts in the states of Maharashtra and Karnataka, India.Parasitology research · 2019Article
- Review of Dancing Parasites in Lymphatic Filariasis.Ultrasound international open · 2019Review
- Biomarkers Associated with Lymphedema and Fibrosis in Patients with Cancer of the Head and Neck.Lymphatic research and biology · 2018Article
- Prospects of developing a prophylactic vaccine against human lymphatic filariasis - evaluation of protection in non-human primates.International journal for parasitology · 2018Article
- Lymphatic Endothelial Cell in Endemic Bancroftian Filariasis: A Focus on the Lymphatics of the Tunica Vaginalis Testis.Journal of tropical medicine · 2018Article
- Microfilariae ofJournal of clinical and diagnostic research : JCDR · 2017Article
- Lymphatic filariasis: A view at pathological diversity.Tropical parasitology · 2014Article
- Dual RNA-seq of parasite and host reveals gene expression dynamics during filarial worm-mosquito interactions.PLoS neglected tropical diseases · 2014Article
- Insights into the pathogenesis of disease in human lymphatic filariasis.Lymphatic research and biology · 2013Review
- Lymphatics: where the circulation meets the immune system.Lymphatic research and biology · 2013Article
- Lymphatic filariasis: perspectives on lymphatic remodeling and contractile dysfunction in filarial disease pathogenesis.Microcirculation (New York, N.Y. : 1994) · 2013Review
- Immunopathogenesis of lymphatic filarial disease.Seminars in immunopathology · 2012Review
- Toll-like receptor- and filarial antigen-mediated, mitogen-activated protein kinase- and NF-κB-dependent regulation of angiogenic growth factors in filarial lymphatic pathology.Infection and immunity · 2012Article
- Circulating microbial products and acute phase proteins as markers of pathogenesis in lymphatic filarial disease.PLoS pathogens · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Lymphatic filariasis characterized by the dysfunction of the lymphatics can lead to severe (and often) irreversible lymphedema and elephantiasis. Decades of research in the field shows that the establishment of the adult parasites in the lymphatics triggers a cascade of events that ultimately results in tissue scarring and fibrosis. In this minireview, we focus on the studies addressing the mechanisms underlying the parasite-induced lymphatic dilatation that suggests parasite-induced lymphatic remodeling and lymphangiogenesis may be the prelude towards developing chronic and irreversible filarial pathology.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.