ArticleJournal of molecular evolution2010
Evolution of Conus peptide genes: duplication and positive selection in the A-superfamily.
Article in Journal of molecular evolution, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Profiling the Paralytic Effects and Lethality of Cone Snail Venom Toxins Using Nanofractionation Analytics withToxins · 2025Article
- Assessing Mechanisms of Potential Local Adaptation Through a Seascape Genomic Approach in a Marine Gastropod, Littoraria flava.Genome biology and evolution · 2024Article
- Molecular Insights into the Low Complexity Secreted Venom of Calliactis polypus.Genome biology and evolution · 2024Article
- Chemical Synthesis and Insecticidal Activity Research Based on α-Conotoxins.Molecules (Basel, Switzerland) · 2024Article
- The Sobering Sting: Oleoyl Serotonin Is a NovelBiomedicines · 2024Article
- Proteomic Analysis of the Predatory Venom ofToxins · 2022Article
- Integrating Venom Peptide Libraries Into a Phylogenetic and Broader Biological Framework.Frontiers in molecular biosciences · 2022Article
- A phylogeny-aware approach reveals unexpected venom components in divergent lineages of cone snails.Proceedings. Biological sciences · 2021Article
- Venom duct origins of prey capture and defensive conotoxins in piscivorous Conus striatus.Scientific reports · 2021Article
- Non-Peptidic Small Molecule Components from Cone Snail Venoms.Frontiers in pharmacology · 2021Review
- Curses or Cures: A Review of the Numerous Benefits Versus the Biosecurity Concerns of Conotoxin Research.Biomedicines · 2020Review
- Conotoxin Diversity in the Venom Gland Transcriptome of the Magician's Cone,Marine drugs · 2019Article
- Lack of Signal for the Impact of Conotoxin Gene Diversity on Speciation Rates in Cone Snails.Systematic biology · 2019Article
- Scorpion Toxins: Positive Selection at a Distal Site Modulates Functional Evolution at a Bioactive Site.Molecular biology and evolution · 2019Article
- High Throughput Identification of Novel Conotoxins from the Vermivorous Oak Cone Snail (International journal of molecular sciences · 2018Article
- Conotoxin Diversity in Chelyconus ermineus (Born, 1778) and the Convergent Origin of Piscivory in the Atlantic and Indo-Pacific Cones.Genome biology and evolution · 2018Article
- Targeted Sequencing of Venom Genes from Cone Snail Genomes Improves Understanding of Conotoxin Molecular Evolution.Molecular biology and evolution · 2018Article
- Venom Insulins of Cone Snails Diversify Rapidly and Track Prey Taxa.Molecular biology and evolution · 2016Article
- Rapid expansion of the protein disulfide isomerase gene family facilitates the folding of venom peptides.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Structural features of conopeptide genes inferred from partial sequences of the Conus tribblei genome.Molecular genetics and genomics : MGG · 2016Article
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3 authors.
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Abstract
A remarkable diversity of venom peptides is expressed in the genus Conus (known as "conotoxins" or "conopeptides"). Between 50 and 200 different venom peptides can be found in a single Conus species, each having its own complement of peptides. Conopeptides are encoded by a few gene superfamilies; here we analyze the evolution of the A-superfamily in a fish-hunting species clade, Pionoconus. More than 90 conopeptide sequences from 11 different Conus species were used to build a phylogenetic tree. Comparison with a species tree based on standard genes reveals multiple gene duplication events, some of which took place before the Pionoconus radiation. By analysing several A-conopeptides from other Conus species recorded in GenBank, we date the major duplication events after the divergence between fish-hunting and non-fish-hunting species. Furthermore, likelihood approaches revealed strong positive selection; the magnitude depends on which A-conopeptide lineage and amino-acid locus is analyzed. The four major A-conopeptide clades defined are consistent with the current division of the superfamily into families and subfamilies based on the Cys pattern. The function of three of these clades (the κA-family, the α4/7-subfamily, and α3/5-subfamily) has previously been characterized. The function of the remaining clade, corresponding to the α4/4-subfamily, has not been elucidated. This subfamily is also found in several other fish-hunting species clades within Conus. The analysis revealed a surprisingly diverse origin of α4/4 conopeptides from a single species, Conus bullatus. This phylogenetic approach that defines different genetic lineages of Conus venom peptides provides a guidepost for identifying conopeptides with potentially novel functions.
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