ArticleWorld journal of pediatrics : WJP2010
Human bocavirus in children with respiratory tract infection in Shanghai: a retrospective study.
Article in World journal of pediatrics : WJP, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Viral spectrum differences between outpatients and inpatients with suspected pediatric acute respiratory infections: a prospective sentinel surveillance study in Pudong, Shanghai, China.BMC infectious diseases · 2026Article
- Molecular epidemiology and whole-genome characterization of human bocavirus in hospitalized children with pneumonia in Suzhou, China, 2022-2025.Virology journal · 2026Article
- Twenty years of human bocavirus research: from an unculturable virus of unclear pathogenicity to a culturable human pathogen and gene therapy vector candidate.Clinical microbiology reviews · 2025Review
- HBoV-1: virus structure, genomic features, life cycle, pathogenesis, epidemiology, diagnosis and clinical manifestations.Frontiers in cellular and infection microbiology · 2023Review
- Human bocavirus-1 screening in infants with acute lower respiratory tract infection.The Journal of international medical research · 2021Article
- Mechanisms Mediating Nuclear Trafficking Involved in Viral Propagation by DNA Viruses.Viruses · 2019Review
- The effects of human parvovirus VP1 unique region in a mouse model of allergic asthma.PloS one · 2019Article
- The VP1 unique region of human parvovirus B19 and human bocavirus induce lung injury in naïve Balb/c mice.PloS one · 2018Article
- A 4 year prospective study to determine risk factors for severe community acquired pneumonia in children in southern China.Pediatric pulmonology · 2013Article
- High human bocavirus viral load is associated with disease severity in children under five years of age.PloS one · 2013Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman bocavirus (HBoV) was first reported in 2005. The worldwide presence of HBoV in children with acute respiratory tract infection (ARTI) has been confirmed. This study aimed to understand the prevalence and clinical features of HBoV in children with ARTI in Shanghai and explore the causative implication of HBoV in ARTI.
methodsWe retrospectively reviewed the medical records of 349 hospitalized children with ARTI between November 2006 and January 2007. From these children, 351 nasopharyngeal aspirate samples were collected; 325 of the samples were obtained from those with community-acquired ARTI and 26 from those with hospital-acquired ARTI. All samples were routinely screened for seven common respiratory viruses by immunofluorescence and further tested for HBoV by polymerase chain reaction.
resultsHBoV was detected in 16 (4.6%) of the 351 samples, and it was the second most commonly detected virus after respiratory syncytial virus. Three (19%) HBoV-positive samples were dual infection with respiratory syncytial virus or parainfluenza virus type 3. Of the 325 children with community-acquired ARTI, HBoV was identified to be positive in 11 (3.4%), of whom 6 were diagnosed with pneumonia with patchy or interstitial infiltrates in the lung indicated by chest radiography, 3 with bronchitis, and 2 with bronchial asthma exacerbation with attendant lung infection. Out of the 26 children with nosocomial ARTI, 5 (19.2%) had bronchitis which was found to be HBoV positive without co-detection of other viruses. The HBoV-positive children were aged 1.7 months to 43 months and their mean age was 13.7 months. Sixteen (100%) children had cough, 11 (68.8%) had wheezing, and 10 (62.5%) had fever.
conclusionsHBoV was circulating in Shanghai during the study period, and which was detected frequently in children with ARTI. HBoV was found to be associated with community-acquired ARTI and may play a pathogenic role in nosocomial ARTI.
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