Evidence map›Paper›PMID 20143197›Full record

ArticleCerebellum (London, England)2010

The cerebellum in children with spina bifida and Chiari II malformation: Quantitative volumetrics by region.

Jenifer Juranek, Maureen Dennis, Paul T Cirino, Lyla El-Messidi, Jack M Fletcher

Open access · greenAbstract read
In one paragraph

Article in Cerebellum (London, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Spina bifida.Nature reviews. Disease primers · 2015
    Review
  9. Review
  10. Article
  11. Article
  12. Imaging the course of a hypoplastic cerebellum in a spina bifida newborn.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2013
    Article
  13. Article
  14. Article
  15. Comment to the paper "Posterior fossa decompression and the cerebellum in Chiari type II malformation: a preliminary MRI study".Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2011
    Article
  16. Posterior fossa decompression and the cerebellum in Chiari type II malformation: a preliminary MRI study.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2011
    Article
  17. Review
  18. The cognitive phenotype of spina bifida meningomyelocele.Developmental disabilities research reviews · 2010
    Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Jenifer JuranekDepartment of Pediatrics, Children's Learning Institute, University of Texas Health Science Center at Houston, Houston, 77030, USA. Jenifer.Juranek@uth.tmc.edu
Maureen Dennis
Paul T Cirino
Lyla El-Messidi
Jack M Fletcher
University of Houston · USHospital for Sick Children · CAThe University of Texas Health Science Center at Houston · US

Funding

SUBJECT RECRUITMENT AND EVALUATION COREP01HD035946 · NICHD · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI FLETCHER, JACK M · 1998 to 2009
$10.8M
Longitudinal Effects of Spina Bifida on LearningR01HD046609 · NICHD · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LANDRY, SUSAN · 2005 to 2009
$2.0M
NICHD NIH HHS P01 HD035946NICHD NIH HHS P01-HD35946NICHD NIH HHS R01 HD046609NICHD NIH HHS R01-HD046609
6 · The paper itself

Abstract

Few volumetric MRI studies of the entire cerebellum have been published; even less quantitative information is available in patients with hindbrain malformations, including the Chiari II malformation which is ubiquitous in patients with spina bifida meningomyelocele (SBM). In the present study, regional volumetric analyses of the cerebellum were conducted in children with SBM/Chiari II and typically developing (TD) children. Total cerebellar volume was significantly reduced in the SBM group relative to the TD group. After correcting for total cerebellum volume, and relative to the TD group, the posterior lobe was significantly reduced in SBM, the corpus medullare was not different, and the anterior lobe was significantly enlarged. Children with thoracic level lesions had smaller cerebellar volumes relative to those with lumbar/sacral lesions, who had smaller volumes compared to TD children. The reduction in cerebellar volume in the group with SBM represents not a change in linear scaling but rather a reconfiguration involving anterior lobe enlargement and posterior lobe reduction.

Indexed as

AdolescentAnalysis of VarianceArnold-Chiari MalformationBrain MappingCerebellumChildFemaleFollow-Up StudiesHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleSpinal Dysraphism

Identifiers

PMID20143197
PMCPMC3046026
OpenAlexW2122620607

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.