ArticleJournal of computational neuroscience2010
Geometry and dynamics of activity-dependent homeostatic regulation in neurons.
Article in Journal of computational neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- When can neuronal activity-dependent homeostatic plasticity maintain circuit-level properties?Journal of computational neuroscience · 2026Article
- Conductance relationships across compartments associated with bursting output in a model of a motor neuron in the crustacean cardiac ganglion.Journal of neurophysiology · 2026Article
- Emergent activity, heterogeneity, and robustness in a calcium feedback model of the sinoatrial node.Biophysical journal · 2023Article
- Article
- Intrinsic plasticity and birdsong learning.Neurobiology of learning and memory · 2021Review
- Modulator-Gated, SUMOylation-Mediated, Activity-Dependent Regulation of Ionic Current Densities Contributes to Short-Term Activity Homeostasis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- The shaping of intrinsic membrane potential oscillations: positive/negative feedback, ionic resonance/amplification, nonlinearities and time scales.Journal of computational neuroscience · 2017Article
- Dynamic compensation mechanism gives rise to period and duty-cycle level sets in oscillatory neuronal models.Journal of neurophysiology · 2016Article
- A Diffusive Homeostatic Signal Maintains Neural Heterogeneity and Responsiveness in Cortical Networks.PLoS computational biology · 2015Article
- Stability of Neuronal Networks with Homeostatic Regulation.PLoS computational biology · 2015Article
- Article
- Animal-to-animal variability in the phasing of the crustacean cardiac motor pattern: an experimental and computational analysis.Journal of neurophysiology · 2013Article
- Differential regulation of HCN channel isoform expression in thalamic neurons of epileptic and non-epileptic rat strains.Neurobiology of disease · 2012Article
- Bifurcations of emergent bursting in a neuronal network.PloS one · 2012Article
- Neuronal homeostasis: time for a change?The Journal of physiology · 2011Review
- Multiple models to capture the variability in biological neurons and networks.Nature neuroscience · 2011Article
- Compensation for variable intrinsic neuronal excitability by circuit-synaptic interactions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Model calcium sensors for network homeostasis: sensor and readout parameter analysis from a database of model neuronal networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
To maintain activity in a functional range, neurons constantly adjust membrane excitability to changing intra- and extracellular conditions. Such activity-dependent homeostatic regulation (ADHR) is critical for normal processing of the nervous system and avoiding pathological conditions. Here, we posed a homeostatic regulation problem for the classical Morris-Lecar (ML) model. The problem was motivated by the phenomenon of the functional recovery of stomatogastric neurons in crustaceans in the absence of neuromodulation. In our study, the regulation of the ionic conductances in the ML model depended on the calcium current or the intracellular calcium concentration. We found an asymptotic solution to the problem under the assumption of slow regulation. The solution provides a full account of the regulation in the case of correlated or anticorrelated changes of the maximal conductances of the calcium and potassium currents. In particular, the solution shows how the target and parameters of the regulation determine which perturbations of the conductances can be compensated by the ADHR. In some cases, the sets of compensated initial perturbations are not convex. On the basis of our analysis we formulated specific questions for subsequent experimental and theoretical studies of ADHR.
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