ArticleMolecular genetics and genomics : MGG2010
A survey of airway responsiveness in 36 inbred mouse strains facilitates gene mapping studies and identification of quantitative trait loci.
Article in Molecular genetics and genomics : MGG, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 31 citations in OpenAlex.
- Genetic background influences developmental airway smooth muscle program and susceptibility to airway hyperresponsiveness in mice.JCI insight · 2026Article
- Genetic background and transient prenatal disruption of vitamin A signaling determine susceptibility to airway hyperresponsiveness in mice.bioRxiv : the preprint server for biology · 2025Article
- Methacholine hyperresponsiveness in mice with house dust mite-induced lung inflammation is not associated with excessive airway constriction ex vivo.Experimental physiology · 2025Article
- Smooth Muscle Hypocontractility and Airway Normoresponsiveness in a Mouse Model of Pulmonary Allergic Inflammation.Frontiers in physiology · 2021Article
- A GWAS approach identifies Dapp1 as a determinant of air pollution-induced airway hyperreactivity.PLoS genetics · 2019Article
- A Genome-Wide Analysis of the Penumbral Volume in Inbred Mice following Middle Cerebral Artery Occlusion.Scientific reports · 2019Article
- Variable Susceptibility to Cigarette Smoke-Induced Emphysema in 34 Inbred Strains of Mice Implicates Abi3bp in Emphysema Susceptibility.American journal of respiratory cell and molecular biology · 2017Article
- Syk Regulates Neutrophilic Airway Hyper-Responsiveness in a Chronic Mouse Model of Allergic Airways Inflammation.PloS one · 2017Article
- Plethysmography Phenotype QTL in Mice Before and After Allergen Sensitization and Challenge.G3 (Bethesda, Md.) · 2016Article
- Mouse genome-wide association study identifies polymorphisms on chromosomes 4, 11, and 15 for age-related cardiac fibrosis.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Article
- Choline Triggers Exacerbations of Chronic Obstructive Pulmonary Disease in Patients Infected withCurrent respiratory medicine reviews · 2016Article
- Article
- Phenotypic characterization of the KK/HlJ inbred mouse strain.Veterinary pathology · 2014Article
- Article
- Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene.PloS one · 2013Article
- Role of reactive nitrogen species generated via inducible nitric oxide synthase in vesicant-induced lung injury, inflammation and altered lung functioning.Toxicology and applied pharmacology · 2012Article
- Pneumocystis elicits a STAT6-dependent, strain-specific innate immune response and airway hyperresponsiveness.American journal of respiratory cell and molecular biology · 2012Article
- Genetic interactions between chromosomes 11 and 18 contribute to airway hyperresponsiveness in mice.PloS one · 2012Article
- Genetic analysis of lung function in inbred mice suggests vitamin D receptor as a candidate gene.Molecular genetics and genomics : MGG · 2011Article
- Identification of the Mhc region as an asthma susceptibility locus in recombinant congenic mice.American journal of respiratory cell and molecular biology · 2011Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Airway hyper-responsiveness (AHR) is a critical phenotype of human asthma and animal models of asthma. Other studies have measured AHR in nine mouse strains, but only six strains have been used to identify genetic loci underlying AHR. Our goals were to increase the genetic diversity of available strains by surveying 27 additional strains, to apply haplotype association mapping to the 36-strain survey, and to identify new genetic determinants for AHR. We derived AHR from the increase in airway resistance in females subjected to increasing levels of methacholine concentrations. We used haplotype association mapping to identify associations between AHR and haplotypes on chromosomes 3, 5, 8, 12, 13, and 14. And we used bioinformatics techniques to narrow the identified region on chromosome 13, reducing the region to 29 candidate genes, with 11 of considerable interest. Our combined use of haplotype association mapping with bioinformatics tools is the first study of its kind for AHR on these 36 strains of mice. Our analyses have narrowed the possible QTL genes and will facilitate the discovery of novel genes that regulate AHR in mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.