Evidence map›Paper›PMID 20143047›Full record

Trial reportInternational urogynecology journal2010

The effects of drug and behavior therapy on urgency and voiding frequency.

Kathryn L Burgio, Stephen R Kraus, Diane Borello-France, Toby C Chai, Kimberly Kenton, Patricia S Goode, Yan Xu, John W Kusek, Urinary Incontinence Treatment Network

Registry-linked trialOpen access · greenAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in International urogynecology journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00090584 (Behavior Enhances Drug Reduction of Incontinence), which is not on this map. Cited by 10 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 5 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00090584 nacompletednot on this map

Behavior Enhances Drug Reduction of Incontinence

TypeinterventionalSponsorCarelon ResearchRan2004 to 2006Enrolled307ConditionsUrinary Incontinence (UI)ArmsTolterodine, Behavioral training
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 5 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Bladder training for treating overactive bladder in adults.The Cochrane database of systematic reviews · 2023
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Article
  7. Review
  8. Review
  9. Review
  10. Overactive bladder - 18 years - Part I.International braz j urol : official journal of the Brazilian Society of Urology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 1 country.

Kathryn L BurgioDepartment of Veterans Affairs, Geriatric Research, Education, and Clinical Center, 11G 700 South 19th Street, Birmingham, AL 35233, USA. kburgio@uab.edu
Stephen R Kraus
Diane Borello-France
Toby C Chai
Kimberly Kenton
Patricia S Goode
Yan Xu
John W Kusek
Urinary Incontinence Treatment Network
University of Alabama at Birmingham · USDuquesne University · USLoyola University Chicago · USNational Institutes of Health · USNew England Research Institutes · USThe University of Texas Health Science Center at San Antonio · USUniversity of Maryland, Baltimore · US

Funding

Urinary Incontinence Treatment Network: DCCU01DK058229 · NIDDK · NEW ENGLAND RESEARCH INSTITUTES, INC. · PI TENNSTEDT, SHARON L · 2000 to 2012
$16.1M
UAB Continence Treatment Center U01DK060380 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI RICHTER, HOLLY E · 2001 to 2009
$3.9M
Urinary Incontinence Treatment NetworkU01DK058225 · NIDDK · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI ZYCZYNSKI, HALINA M · 2000 to 2009
$3.8M
UCSD INCONTINENCE TREATMENT CENTERU01DK060401 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALBO, MICHAEL · 2001 to 2010
$3.6M
Continuation of the Urinary Incontinence Treatment Network (UITN)U01DK060379 · NIDDK · LOYOLA UNIVERSITY CHICAGO · PI BRUBAKER, LINDA · 2001 to 2009
$3.6M
UTAH URINARY INCONTINENCE TREATMENT NETWORK (UUITN)U01DK060393 · NIDDK · UNIVERSITY OF UTAH · PI NORTON, PEGGY A · 2001 to 2009
$3.4M
Urinary Incontinence Treatment NetworkU01DK058231 · NIDDK · WILLIAM BEAUMONT HOSPITAL RESEARCH INST · PI SIRLS, LARRY T · 2000 to 2009
$3.3M
Urinary Incontinence Treatment Network (UITN)U01DK060397 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI CHAI, TOBY C · 2001 to 2010
$2.7M
Urinary Incontinence Treatment NetworkU01DK060395 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI ZIMMERN, PHILIPPE E · 2001 to 2009
$2.4M
The Urinary Incontinence Treatment NetworkU01DK058234 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI KRAUS, STEPHEN R · 2000 to 2009
$2.3M
NIDDK NIH HHS U01 DK058225NIDDK NIH HHS U01 DK058229NIDDK NIH HHS U01 DK058231NIDDK NIH HHS U01 DK058234NIDDK NIH HHS U01 DK060379NIDDK NIH HHS U01 DK060380NIDDK NIH HHS U01 DK060393NIDDK NIH HHS U01 DK060395NIDDK NIH HHS U01 DK060397NIDDK NIH HHS U01 DK060401NIDDK NIH HHS U01 DK58225NIDDK NIH HHS U01 DK58229NIDDK NIH HHS U01 DK58231NIDDK NIH HHS U01 DK58234NIDDK NIH HHS U01 DK60379NIDDK NIH HHS U01DK60380NIDDK NIH HHS U01 DK60393NIDDK NIH HHS U01 DK60395NIDDK NIH HHS U01DK60397NIDDK NIH HHS U01 DK60401
6 · The paper itself

Abstract

introduction and hypothesisThe objective of this study was to examine the effects of drug therapy alone and combined with behavioral therapy on urgency and 24-voiding frequency in women with urge-predominant incontinence and to identify predictors of change.

methodsA planned analysis of data from a multi-site, randomized, controlled trial (N = 307). Bladder diaries were used to document voids, incontinence, and urgency severity.

resultsUrgency scores decreased significantly within both treatment groups, but changes did not differ between groups (p = 0.30). Improvement in urgency was associated with greater baseline urgency (p < 0.0001) and black ethnicity (p = 0.03). Voiding frequency increased with drug alone and decreased slightly with combined therapy (p = 0.009), and improvement was associated with combined treatment (p < 0.0001), higher baseline frequency (p < 0.0001), and lower baseline incontinence episode frequency (p = 0.001).

conclusionsAlthough combined drug and behavioral therapy does not appear to improve urgency more than drug alone, it resulted in better outcomes on voiding frequency.

Indexed as

Behavior TherapyExercise TherapyAdultAgedAged, 80 and overBenzhydryl CompoundsCombined Modality TherapyCresolsFemaleHumansMiddle AgedMuscarinic AntagonistsPhenylpropanolamineTolterodine TartrateTreatment OutcomeUrinary Incontinence, UrgeBenzhydryl CompoundsCresolsMuscarinic AntagonistsPhenylpropanolamineTolterodine Tartrate

Identifiers

PMID20143047
PMCPMC3119359
OpenAlexW2063980514

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.