ArticleExperimental & translational stroke medicine2009
Long term immunologic consequences of experimental stroke and mucosal tolerance.
Article in Experimental & translational stroke medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
- Molecular Mechanisms of Neuroimmune Crosstalk in the Pathogenesis of Stroke.International journal of molecular sciences · 2021Review
- The immune response of T cells and therapeutic targets related to regulating the levels of T helper cells after ischaemic stroke.Journal of neuroinflammation · 2021Review
- Adaptive Immunity Regulation and Cerebral Ischemia.Frontiers in immunology · 2020Review
- Protective and Regenerative Roles of T Cells in Central Nervous System Disorders.Frontiers in immunology · 2019Review
- Immunomodulatory Therapeutic Strategies in Stroke.Frontiers in pharmacology · 2019Review
- Emerging Role of Immunity in Cerebral Small Vessel Disease.Frontiers in immunology · 2018Review
- The role of carbon monoxide and heme oxygenase in the prevention of sickle cell disease vaso-occlusive crises.American journal of hematology · 2017Review
- Article
- Promiscuity of autoimmune responses to MBP after stroke.Journal of neuroimmunology · 2015Article
- Blocking stroke-induced immunodeficiency increases CNS antigen-specific autoreactivity but does not worsen functional outcome after experimental stroke.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- The ischemic environment drives microglia and macrophage function.Frontiers in neurology · 2015Review
- Variation in behavioral deficits and patterns of recovery after stroke among different rat strains.Translational stroke research · 2014Article
- Repetitive hypoxic preconditioning induces an immunosuppressed B cell phenotype during endogenous protection from stroke.Journal of neuroinflammation · 2014Article
- Antigen-specific immune reactions to ischemic stroke.Frontiers in cellular neuroscience · 2014Review
- The immunologic profile of adoptively transferred lymphocytes influences stroke outcome of recipients.Journal of neuroimmunology · 2013Article
- Leukocytosis in patients with neurologic deterioration after acute ischemic stroke is associated with poor outcomes.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2013Article
- Regulatory T cells accumulate and proliferate in the ischemic hemisphere for up to 30 days after MCAO.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2013Article
- Regulatory T cell in stroke: a new paradigm for immune regulation.Clinical & developmental immunology · 2013Review
- Activation of immune responses to brain antigens after stroke.Journal of neurochemistry · 2012Article
- Autoimmune responses to brain following stroke.Translational stroke research · 2012Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAn inflammatory insult following middle cerebral artery occlusion (MCAO) is associated with a predisposition to develop a deleterious autoimmune response to the brain antigen myelin basic protein (MBP). Induction of immunologic tolerance to brain antigens prior to MCAO prevents this deleterious autoimmune response and is associated with better functional outcome early after stroke. In this study, we sought to determine the long term immunologic consequences of experimental stroke and induction of mucosal tolerance.
methodsMale Lewis rats were tolerized to MBP or ovalbumin (OVA) by intranasal administration prior to MCAO and administration of lipopolysaccharide (LPS). Neurological outcome was assessed at set points after MCAO and animals sacrificed at 3 months; the immune response to MBP in brain and spleen was determined using ELISPOT assay and degree of cellular inflammatory brain infiltrate assessed by immunocytochemistry.
resultsAnimals that developed a pro-inflammatory (TH1) response to MBP experienced worse outcome, while those that developed a regulatory response (TREG) experienced better outcome. A TREG response in spleen was also associated with decreased inflammation and an increase in the number of FoxP3 positive cells in brain. In this study, tolerization to MBP prior to MCAO was associated with a tendency to develop a TH1 response to MBP by 3 months after MCAO.
conclusionThese data show that induction of immunological tolerance to MBP is associated with improved outcome after stroke. This study, however, raises concern about the potential for inadvertent induction of detrimental autoimmunity through mucosal administration of antigen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.