ArticleInternational journal of diabetes in developing countries2009
Approaches in type 1 diabetes research: A status report.
Article in International journal of diabetes in developing countries, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 33 citations in OpenAlex.
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- Identifying spatial variation in the burden of diabetes among women across 640 districts in India: a cross-sectional study.Journal of diabetes and metabolic disorders · 2020Article
- An Overview on Probiotics as an Alternative Strategy for Prevention and Treatment of Human Diseases.Iranian journal of pharmaceutical research : IJPR · 2019Review
- Management of Graft Duodenal Leak in Simultaneous Pancreas Kidney Transplant-a Case Report from India and Review of Literature.The Indian journal of surgery · 2016Review
- A qualitative study of perceptions of determinants of disease burden among young patients with type 1 diabetes and their parents in South India.Diabetes, metabolic syndrome and obesity : targets and therapy · 2016Article
- Type 1 diabetes guidelines: Are they enough?Indian journal of endocrinology and metabolism · 2015Article
- Management of type 1 diabetes in children and adolescents.Indian journal of pediatrics · 2014Review
- Type 1 diabetes research: Newer approaches and exciting developments.International journal of diabetes in developing countries · 2009Article
- Current Indicators of Nutritional Care in Children with Type 1 Diabetes in India: Do we Need a National Nutritional Guideline?Indian journal of endocrinology and metabolismArticle
- Medical Nutrition Therapy in Type 1 Diabetes Mellitus.Indian journal of endocrinology and metabolismArticle
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Authors and funding
7 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Type 1 diabetes is a multifactorial disease with an early age of onset, in which the insulin producing beta cell of the pancreas are destroyed because of autoimmunity. It is the second most common chronic disease in children and account for 5% to 10% of all diagnosed cases of diabetes. India is having an incidence of 10.6 cases/year/100,000, and recent studies indicate that the prevalence of type 1 diabetes in India is increasing. However in view of poor health care network, there is no monitoring system in the country. Of the 18 genomic intervals implicated for the risk to develop type 1 diabetes, the major histocompatibility complex (MHC) region on chromosome 6p21.31 has been the major contributor estimated to account for 40-50%, followed by 10% frequency of INS-VNTR at 5' flanking region of the insulin gene on chromosome 11p15.5. However, population studies suggest that > 95% of type 1 diabetes have HLA-DR3 or DR4, or both, and in family studies, sibling pairs affected with type 1 diabetes have a non-random distribution of shared HLA haplotypes. As predisposing genetic factors such as HLA alleles are known, immunological interventions to prevent type 1 diabetes are of great interest. In the present study we have reviewed the status of molecular genetics of the disease and the approaches that need to be adopted in terms of developing patient and suitable control cohorts in the country.
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