Evidence map›Paper›PMID 20142834›Full record

ReviewNature reviews. Genetics2010

Establishing, maintaining and modifying DNA methylation patterns in plants and animals.

Julie A Law, Steven E Jacobsen

Abstract readReview
In one paragraph

Review in Nature reviews. Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1,899 papers.

0numbers the graph read from it
0cells of the map it votes in
1,899citing papers in PubMed
246.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1,899 citing papers in PubMed, 3,920 citations in OpenAlex.

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  5. Beyond Deterministic Fetal Programming: Intrauterine Exposures and the Multifactorial Origins of Adiposity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
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  14. Telomere-to-telomere genome ofHorticulture research · 2026
    Article
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1,839 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Julie A LawDepartment of Molecular, Cell and Developmental Biology, University of California-Los Angeles, 90095-1606, USA.
Steven E Jacobsen
Howard Hughes Medical Institute · US

Funding

Genetics of DNA methylation patterning of arabidopsis.R37GM060398 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JACOBSEN, STEVEN E · 2009 to 2018
$3.0M
Genetics of DNA Methylation Patterning of ArabidopsisR01GM060398 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JACOBSEN, STEVEN E · 2000 to 2008
$2.2M
NIGMS NIH HHS 5F32GM820453NIGMS NIH HHS GM60398NIGMS NIH HHS R37 GM060398
6 · The paper itself

Abstract

Cytosine DNA methylation is a stable epigenetic mark that is crucial for diverse biological processes, including gene and transposon silencing, imprinting and X chromosome inactivation. Recent findings in plants and animals have greatly increased our understanding of the pathways used to accurately target, maintain and modify patterns of DNA methylation and have revealed unanticipated mechanistic similarities between these organisms. Key roles have emerged for small RNAs, proteins with domains that bind methylated DNA and DNA glycosylases in these processes. Drawing on insights from both plants and animals should deepen our understanding of the regulation and biological significance of DNA methylation.

Indexed as

AnimalsCpG IslandsDNA MethylationDNA, PlantEpigenesis, GeneticGametogenesisHistonesModels, GeneticPlantsRNA, Small InterferingDNA, PlantHistonesRNA, Small Interfering

Identifiers

PMID20142834
PMCPMC3034103
OpenAlexW2026343134

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.