ReviewMolecular psychiatry2010
Translational research in bipolar disorder: emerging insights from genetically based models.
Review in Molecular psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 95 citations in OpenAlex.
- Lithium-induced neuroprotection in bipolar disorder: Translational insights into cytoskeletal and proteomic mechanisms.IBRO neuroscience reports · 2025Review
- Enlightened: addressing circadian and seasonal changes in photoperiod in animal models of bipolar disorder.Translational psychiatry · 2021Review
- COVID-19 patient transcriptomic and genomic profiling reveals comorbidity interactions with psychiatric disorders.Translational psychiatry · 2021Article
- Toll-like receptor 2 (TLR2)-deficiency impairs male mouse recovery from a depression-like state.Brain, behavior, and immunity · 2020Article
- No differences in manic-like behaviors between voluntary ethanol and water drinking in Lateral Hypothalamic Kindled (LHK) alcohol preferring rats.Psychiatry research · 2018Article
- Deficiency of Shank2 causes mania-like behavior that responds to mood stabilizers.JCI insight · 2017Article
- Forebrain-specific ablation of phospholipase Cγ1 causes manic-like behavior.Molecular psychiatry · 2017Article
- Striatal Transcriptome and Interactome Analysis ofFrontiers in molecular neuroscience · 2017Article
- Article
- Investigating the mechanism(s) underlying switching between states in bipolar disorder.European journal of pharmacology · 2015Review
- Abnormal development of monoaminergic neurons is implicated in mood fluctuations and bipolar disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Lateral hypothalamic kindling induces manic-like behavior in rats: a novel animal model.International journal of bipolar disorders · 2014Article
- Changes in mitochondrial function are pivotal in neurodegenerative and psychiatric disorders: how important is BDNF?British journal of pharmacology · 2014Review
- Are BDNF and glucocorticoid activities calibrated?Neuroscience · 2013Review
- Inflammatory T helper 17 cells promote depression-like behavior in mice.Biological psychiatry · 2013Article
- Modulation of neuronal plasticity following chronic concomitant administration of the novel antipsychotic lurasidone with the mood stabilizer valproic acid.Psychopharmacology · 2013Article
- The role of the serotonergic and GABA system in translational approaches in drug discovery for anxiety disorders.Frontiers in pharmacology · 2013Article
- Impaired mitochondrial function in psychiatric disorders.Nature reviews. Neuroscience · 2012Review
- Review of pharmacological treatment in mood disorders and future directions for drug development.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Review
- GSK-3 and Wnt Signaling in Neurogenesis and Bipolar Disorder.Frontiers in molecular neuroscience · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Bipolar disorder (BPD) is characterized by vulnerability to episodic depression and mania and spontaneous cycling. Because of marked advances in candidate-gene and genome-wide association studies, the list of risk genes for BPD is growing rapidly, creating an unprecedented opportunity to understand the pathophysiology of BPD and to develop novel therapeutics for its treatment. However, genetic findings are associated with major unresolved issues, including whether and how risk variance leads to behavioral abnormalities. Although animal studies are key to resolving these issues, consensus is needed regarding how to define and monitor phenotypes related to mania, depression and mood swing vulnerability in genetically manipulated rodents. In this study we discuss multiple facets of this challenging area, including theoretical considerations, available tests, limitations associated with rodent behavioral modeling and promising molecular-behavioral findings. These include CLOCK, glycogen synthase kinase 3beta (GSK-3beta), glutamate receptor 6 (GluR6), extracellular signal-regulated kinase-1 (ERK1), p11 (or S100A10), vesicular monoamine transporter 2 (VMAT2 or SLC18A2), glucocorticoid receptors (GRs), Bcl-2-associated athanogene-1 (BAG1) and mitochondrial DNA polymerase-gamma (POLG). Some mutant rodent strains show behavioral clusters or activity patterns that cross-species phenocopy objective/observable facets of mood syndromes, and changes in these clustered behaviors can be used as outcome measures in genetic-behavioral research in BPD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.