Evidence map›Paper›PMID 20142543›Full record

Trial reportArchives of ophthalmology (Chicago, Ill. : 1960)2010

Relationship of blood pressure to retinal vessel diameter in type 1 diabetes mellitus.

Ronald Klein, Chelsea E Myers, Barbara E K Klein, Bernard Zinman, Robert Gardiner, Samy Suissa, Alan R Sinaiko, Sandra M Donnelly, Paul Goodyer, Trudy Strand and 1 more

Registry-linked trialOpen access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Archives of ophthalmology (Chicago, Ill. : 1960), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00143949 (Renin Angiotensin System Blockage-DN), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00143949 phase2completednot on this map

Renin Angiotensin System Blockage-DN (RASS)

TypeinterventionalSponsorMichael Mauer, MDRan1997 to 2008Enrolled285ConditionsType 1 DiabetesArmsenalapril, losartan
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. How does hypertension affect your eyes?Journal of human hypertension · 2012
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Ronald KleinDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, 610 N Walnut St, 417 WARF, Madison, WI 53726-2336, USA. kleinr@epi.ophth.wisc.edu
Chelsea E Myers
Barbara E K Klein
Bernard Zinman
Robert Gardiner
Samy Suissa
Alan R Sinaiko
Sandra M Donnelly
Paul Goodyer
Trudy Strand
Michael Mauer
University of Wisconsin–Madison · US

Funding

YOUTH DRUG ABUSE, ADHD, AND RELATED DISRUPTIVE DISORDERSM01RR000400 · NCRR · UNIVERSITY OF MINNESOTA TWIN CITIES · PI BACHANOVA, VERONIKA S · 1985 to 2009
$33.7M
Renin Angiotensin System Blockage-DN (RASS)R01DK051975 · NIDDK · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MAUER, S MICHAEL · 1997 to 2007
$7.0M
EPIDEMIOLOGY OF DIABETIC RETINOPATHYR03EY012198 · NEI · UNIVERSITY OF WISCONSIN MADISON · PI KLEIN, RONALD · 1998 to 1999
–
CIHR DCT 14281NCRR NIH HHS M01 RR000400NCRR NIH HHS M01 RR 00400NEI NIH HHS EY12198NEI NIH HHS R03 EY012198NIDDK NIH HHS DK51975NIDDK NIH HHS R01 DK051975
6 · The paper itself

Abstract

objectiveTo examine the relationship of blood pressure (BP) and use of angiotensin-receptor blocker or angiotensin-converting enzyme inhibitor to retinal vessel diameter in normotensive, normoalbuminuric persons with type 1 diabetes mellitus.

methodsIn a randomized, controlled clinical trial, clinic and 24-hour ambulatory BPs were measured in persons with type 1 diabetes mellitus and gradable fundus photographs both at baseline (n = 147) and at 5-year follow-up (n = 124). Retinal arteriole and venule diameters were measured by a computer-assisted technique. Individual arteriole and venule measurements were combined into summary indexes that reflect the average retinal arteriole (central retinal arteriole equivalent [CRAE]) and venule (central retinal venule equivalent [CRVE]) diameter of an eye, respectively.

resultsWhile controlling for age, study site, glycosylated hemoglobin level, and ambulatory pulse rate, the daytime ambulatory systolic (-0.29-microm effect per 1 mm Hg; P = .02), daytime ambulatory diastolic (-0.44-microm effect per 1 mm Hg; P = .04), nighttime ambulatory systolic (-0.27-microm effect per 1 mm Hg; P = .03), and 24-hour ambulatory systolic (-0.31-microm effect per 1 mm Hg; P = .03) BPs were cross-sectionally associated with a smaller CRAE. While controlling for age, study site, glycosylated hemoglobin level, ambulatory pulse rate, and baseline CRAE, no BP measure was associated with a change in CRAE or CRVE during 5 years of follow-up. Treatment with losartan potassium or enalapril maleate was not associated with a statistically significant change in CRAE or CRVE.

conclusionAngiotensin-converting enzyme inhibitor or angiotensin-receptor blocker therapy does not affect retinal arteriole or venule diameter in normotensive persons with type 1 diabetes mellitus. Trial Registration clinicaltrials.gov Identifier: NCT00143949.

Indexed as

AdolescentAdultAngiotensin-Converting Enzyme InhibitorsAngiotensin II Type 1 Receptor BlockersArteriolesBlood PressureBlood Pressure Monitoring, AmbulatoryCircadian RhythmDiabetes Mellitus, Type 1Double-Blind MethodEnalaprilFemaleGlycated HemoglobinHeart RateHumansImage Processing, Computer-AssistedAngiotensin-Converting Enzyme InhibitorsAngiotensin II Type 1 Receptor BlockersEnalaprilGlycated HemoglobinLosartan

Identifiers

PMID20142543
PMCPMC2945902
OpenAlexW2131150517

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.