ArticleProceedings of the National Academy of Sciences of the United States of America2010
Induction and patterning of trunk and tail neural ectoderm by the homeobox gene eve1 in zebrafish embryos.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Transposon insertion causes ctnnb2 transcript instability that results in the maternal effect zebrafish ichabod (ich) mutation.Biochimica et biophysica acta. Gene regulatory mechanisms · 2025Article
- Molecular asymmetry in the cephalochordate embryo revealed by single-blastomere transcriptome profiling.PLoS genetics · 2020Article
- Intracellular Communication among Morphogen Signaling Pathways during Vertebrate Body Plan Formation.Genes · 2020Review
- Organization of Embryonic Morphogenesis via Mechanical Information.Developmental cell · 2019Article
- Zebrafish Znfl1 proteins control the expression ofThe Journal of biological chemistry · 2017Article
- The genome of the Gulf pipefish enables understanding of evolutionary innovations.Genome biology · 2016Article
- Evx1 and Evx2 specify excitatory neurotransmitter fates and suppress inhibitory fates through a Pax2-independent mechanism.Neural development · 2016Article
- Early lineage restriction in temporally distinct populations of Mesp1 progenitors during mammalian heart development.Nature cell biology · 2014Article
- Article
- IMP: a multi-species functional genomics portal for integration, visualization and prediction of protein functions and networks.Nucleic acids research · 2012Article
- Article
- Correct anteroposterior patterning of the zebrafish neurectoderm in the absence of the early dorsal organizer.BMC developmental biology · 2011Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
In vertebrates, Evx homeodomain transcription factor-encoding genes are expressed in the posterior region during embryonic development, and overexpression experiments have revealed roles in tail development in fish and frogs. We analyzed the molecular mechanisms of posterior neural development and axis formation regulated by eve1. We show that eve1 is involved in establishing trunk and tail neural ectoderm by two independent mechanisms: First, eve1 posteriorizes neural ectoderm via induction of aldh1a2, which encodes an enzyme that synthesizes retinoic acid; second, eve1 is involved in neural induction in the posterior ectoderm by attenuating BMP expression. Further, eve1 can restore trunk neural tube formation in the organizer-deficient ichabod(-/-) mutant. We conclude that eve1 is crucial for the organization of the antero-posterior and dorso-ventral axis in the gastrula ectoderm and also has trunk- and tail-promoting activity.
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Registered trials
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