ArticleThe Journal of experimental medicine2010
Human NKp44+IL-22+ cells and LTi-like cells constitute a stable RORC+ lineage distinct from conventional natural killer cells.
Article in The Journal of experimental medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers.
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Who cites it
131 citing papers in PubMed, 244 citations in OpenAlex.
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- Immune landscape and immunotherapy of hepatocellular carcinoma: focus on innate and adaptive immune cells.Clinical and experimental medicine · 2023Review
- ILC3: a case of conflicted identity.Frontiers in immunology · 2023Review
- Microbiota-derived tryptophan metabolites in vascular inflammation and cardiovascular disease.Amino acids · 2022Review
- Human ILC3 Exert TRAIL-Mediated Cytotoxicity Towards Cancer Cells.Frontiers in immunology · 2022Article
- No Significant Effects of IL-23 on Initiating and Perpetuating the Axial Spondyloarthritis: The Reasons for the Failure of IL-23 Inhibitors.Frontiers in immunology · 2022Review
- GATA2 haploinsufficient patients lack innate lymphoid cells that arise after hematopoietic cell transplantation.Frontiers in immunology · 2022Article
- Innate lymphoid cells: NK and cytotoxic ILC3 subsets infiltrate metastatic breast cancer lymph nodes.Oncoimmunology · 2022Article
- Identification of human cytotoxic ILC3s.European journal of immunology · 2021Article
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- Human Innate Lymphoid Cells in Influenza Infection and Vaccination.Critical reviews in immunology · 2021Review
- CD5 Surface Expression Marks Intravascular Human Innate Lymphoid Cells That Have a Distinct Ontogeny and Migrate to the Lung.Frontiers in immunology · 2021Article
- Notch Regulates Innate Lymphoid Cell Plasticity during Human NK Cell Development.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- Plasticity of innate lymphoid cell subsets.Nature reviews. Immunology · 2020Review
- Innate Lymphocytes in Psoriasis.Frontiers in immunology · 2020Review
- Lung Innate Lymphoid Cell Composition Is Altered in Primary Graft Dysfunction.American journal of respiratory and critical care medicine · 2020Article
- Interleukin-17A Interweaves the Skeletal and Immune Systems.Frontiers in immunology · 2020Review
- Innate Lymphoid Cells at the Maternal-Fetal Interface in Human Pregnancy.International journal of biological sciences · 2020Review
71 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lymphoid tissue inducer (LTi) cells are required for lymph node formation during fetal development, and recent evidence implies a role in mucosal immunity in the adult. LTi cells share some phenotypic features of conventional natural killer (NK; cNK) cells; however, little is known to date about the relationship between these two cell types. We show that lineage(-) (Lin(-)) CD127(+)RORC(+) LTi-like cells in human tonsil are precursors to CD56(+)CD127(+)RORC(+)NKp46(+) cells, which together comprise a stable RORC(+) lineage. We find that LTi-like cells and their CD56(+) progeny can be expanded and cloned ex vivo without loss of function and without conversion into cNK cells. Clonal analysis reveals heterogeneity of cytokine production within the CD127(+) LTi-like population. Furthermore, we identify within the tonsil a cNK precursor population that is characterized as Lin(-)CD117(+)CD161(+)CD127(-) cells. Overall, we propose that CD127(+)RORC(+) cells, although they share some characteristics with cNK cells, represent a functionally and developmentally distinct lineage.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.