ArticleThe Journal of physiology2010
Autonomic control of heart rate by metabolically sensitive skeletal muscle afferents in humans.
Article in The Journal of physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 131 citations in OpenAlex.
- Aerobic Cycling Exercise Training Does Not Improve Impaired Vagal Reactivation in Patients with Chronic Kidney Disease.Medicine and science in sports and exercise · 2025Trial
- Cardiorespiratory responses to muscle metaboreflex activation in fibrosing interstitial lung disease.Experimental physiology · 2022Trial
- The effect of slow-loaded breathing training on the blood pressure response to handgrip exercise in patients with isolated systolic hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2017Trial
- Ischemic preconditioning reduces hemodynamic response during metaboreflex activation.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Trial
- Influence of the Metaboreflex on Pulmonary Vascular Capacitance in Heart Failure.Medicine and science in sports and exercise · 2016Trial
- Intrathecal fentanyl blockade of afferent neural feedback from skeletal muscle during exercise in heart failure patients: Influence on circulatory power and pulmonary vascular capacitance.International journal of cardiology · 2015Trial
- Effect of muscle metaboreflex activation on spontaneous cardiac baroreflex sensitivity during exercise in humans.The Journal of physiology · 2011Trial
- Whole-body vibration attenuates the increase in leg arterial stiffness and aortic systolic blood pressure during post-exercise muscle ischemia.European journal of applied physiology · 2011Trial
- Muscle metaboreflex activation by static exercise dilates pupil in humans.European journal of applied physiology · 2011Trial
- Autonomic cardiovascular changes during reactive hyperemia.Clinical physiology and functional imaging · 2026Article
- Autonomic control of cardiac rhythm at the onset of muscle metaboreflex activation following exercise in healthy young and old adults.Physiological reports · 2026Article
- The influence of metaboreflex activation on pulmonary pressure with combined chemoreflex activation in acute and chronic hypoxia.The Journal of physiology · 2026Article
- Prognostic value of exercise blood pressure: role of fitness and exercise training.American journal of physiology. Heart and circulatory physiology · 2026Review
- Mechanisms mediating muscle metaboreflex control of cardiac output during exercise: Impaired regulation in heart failure.Experimental physiology · 2025Review
- Influence of blood lactate variations and passive exercise on cardiac responses.Journal of physical therapy science · 2024Article
- Muscle metaboreflex stimulates the cardiac sympathetic afferent reflex causing positive feedback amplification of sympathetic activity: effect of heart failure.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Augmented sympathoexcitation slows postexercise heart rate recovery.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Immediate and sustained increases in the activity of vagal preganglionic neurons during exercise and after exercise training.Cardiovascular research · 2023Article
- Muscle metaboreflex activation during hypercapnia modifies nonlinear heart rhythm dynamics, increasing the complexity of the sinus node autonomic regulation in humans.Pflugers Archiv : European journal of physiology · 2023Article
- The exercise pressor reflex: An update.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Review
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6 authors at 3 institutions in 3 countries.
Funding
Abstract
Isolated activation of metabolically sensitive skeletal muscle afferents (muscle metaboreflex) using post-exercise ischaemia (PEI) following handgrip partially maintains exercise-induced increases in arterial blood pressure (BP) and muscle sympathetic nerve activity (SNA), while heart rate (HR) declines towards resting values. Although masking of metaboreflex-mediated increases in cardiac SNA by parasympathetic reactivation during PEI has been suggested, this has not been directly tested in humans. In nine male subjects (23 +/- 5 years) the muscle metaboreflex was activated by PEI following moderate (PEI-M) and high (PEI-H) intensity isometric handgrip performed at 25% and 40% maximum voluntary contraction, under control (no drug), parasympathetic blockade (glycopyrrolate) and beta-adrenergic blockade (metoprolol or propranalol) conditions, while beat-to-beat HR and BP were continuously measured. During control PEI-M, HR was slightly elevated from rest (+3 +/- 2 beats min(-1)); however, this HR elevation was abolished with beta-adrenergic blockade (P < 0.05 vs. control) but augmented with parasympathetic blockade (+8 +/- 2 beats min(-1), P < 0.05 vs. control and beta-adrenergic blockade). The HR elevation during control PEI-H (+9 +/- 3 beats min(-1)) was greater than with PEI-M (P < 0.05), and was also attenuated with beta-adrenergic blockade (+4 +/- 2 beats min(-1), P < 0.05 vs. control), but was unchanged with parasympathetic blockade (+9 +/- 2 beats min(-1), P > 0.05 vs. control). BP was similarly increased from rest during PEI-M and further elevated during PEI-H (P < 0.05) in all conditions. Collectively, these findings suggest that the muscle metaboreflex increases cardiac SNA during PEI in humans; however, it requires a robust muscle metaboreflex activation to offset the influence of cardiac parasympathetic reactivation on heart rate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.