Evidence map›Paper›PMID 20142026›Full record

ArticleJournal of cardiac failure2010

Medication adherence is a mediator of the relationship between ethnicity and event-free survival in patients with heart failure.

Jia-Rong Wu, Terry A Lennie, Marla J De Jong, Susan K Frazier, Seongkum Heo, Misook L Chung, Debra K Moser

Abstract readComparative Study
In one paragraph

Article in Journal of cardiac failure, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Review
  5. Precipitating Factors for Hospitalization with Heart Failure: Prevalence and Clinical Impact Observations from the Gulf CARE (Gulf aCute heArt failuRe rEgistry).Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2020
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Cardiovascular risk.British journal of clinical pharmacology · 2012
    Review
  13. Medication adherence: emerging use of technology.Current opinion in cardiology · 2011
    Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Jia-Rong WuUniversity of Kentucky, College of Nursing, Lexington, KY 40536-0232, USA. jiarongwu@uky.edu
Terry A Lennie
Marla J De Jong
Susan K Frazier
Seongkum Heo
Misook L Chung
Debra K Moser

Funding

YOGA, IMMUNE FUNCTION, AND HEALTHM01RR000034 · NCRR · OHIO STATE UNIVERSITY · PI PASKETT, ELECTRA D. · 1985 to 2008
$22.7M
XENOBIOTIC TRANSFER INTO MILK NITROFURANTOINM01RR002602 · NCRR · UNIVERSITY OF KENTUCKY · PI BLONDER, LEE XENAKIS · 1985 to 2007
$12.1M
Biobehavioral Intervention in Heart FailureR01NR008567 · NINR · UNIVERSITY OF KENTUCKY · PI MOSER, DEBRA KAY · 2004 to 2008
$1.5M
Self-Management Pilot/Feasibility and Biobehavioral Outcomes CoreP20NR010679 · NINR · UNIVERSITY OF KENTUCKY · PI HALL, LYNNE ANDERSON · 2007 to 2011
$1.2M
NCRR NIH HHS M01 RR000034NCRR NIH HHS M01 RR002602NCRR NIH HHS M01RR02602NINR NIH HHS 1P20NR010679.NINR NIH HHS P20 NR010679NINR NIH HHS R01 NR008567
6 · The paper itself

Abstract

backgroundRehospitalization rates are higher in African American than Caucasian patients with heart failure (HF). The reasons for the disparity in outcomes between African Americans and Caucasians may relate to differences in medication adherence. To determine whether medication adherence is a mediator of the relationship between ethnicity and event-free survival in patients with HF. METHODS AND

resultsMedication adherence was monitored longitudinally in 135 HF patients using the Medication Event Monitoring System. Events (emergency department visits for HF exacerbation, HF and cardiac rehospitalization, and all-cause mortality) were obtained by interview and hospital data base review. A series of regression models and survival analyses was conducted to determine whether medication adherence mediated the relationship between ethnicity and event-free survival. Event-free survival was significantly worse in African Americans than Caucasians. Ethnicity was a predictor of medication adherence (P=.011). African Americans were 2.57 times more likely to experience an event than Caucasians (P=.026). Ethnicity was not a predictor of event-free survival after entering medication adherence in the model (P=.06).

conclusionsMedication adherence was a mediator of the relationship between ethnicity and event-free survival in this sample. Interventions designed to reduce barriers to medication adherence may decrease the disparity in outcomes.

Indexed as

AgedBlack or African AmericanDisease-Free SurvivalEthnicityFemaleFollow-Up StudiesHeart FailureHumansLongitudinal StudiesMaleMedication AdherenceMiddle AgedProspective StudiesTreatment OutcomeWhite People

Identifiers

PMID20142026
PMCPMC2819978

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.