ArticleBiophysical journal2010
Physical model of the dynamic instability in an expanding cell culture.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed.
- Gene-driven self-morphing microtubule-based active matter.Nature materials · 2026Article
- Substrate heterogeneity promotes cancer cell dissemination through interface roughening.Science advances · 2026Article
- Clusters, fingers, and singles: A mechanical landscape of tumor invasion.PLoS computational biology · 2026Article
- Measurement of tissue viscosity to relate force and motion in collective cell migration.Soft matter · 2026Article
- [The Dynamic Model of the Active-Inactive Cell Interface].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024Article
- Fractal dimension to characterize interactions between blood and lymphatic endothelial cells.Physical biology · 2023Article
- Dominant geometrical factors of collective cell migration in flexible 3D gelatin tube structures.Biophysical reports · 2022Article
- Photothermal Agarose Microfabrication Technology for Collective Cell Migration Analysis.Micromachines · 2021Article
- Article
- Reversible elastic phase field approach and application to cell monolayers.The European physical journal. E, Soft matter · 2020Article
- Autocrine inhibition of cell motility can drive epithelial branching morphogenesis in the absence of growth.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Size-Regulated Symmetry Breaking in Reaction-Diffusion Models of Developmental Transitions.Cells · 2020Article
- Why does epithelia display heterogeneity? Bridging physical and biological concepts.Biophysical reviews · 2019Article
- Dynamics phenotyping across length and time scales in collective cell migration.Seminars in cell & developmental biology · 2019Review
- Motility-limited aggregation of mammary epithelial cells into fractal-like clusters.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Switch-like enhancement of epithelial-mesenchymal transition by YAP through feedback regulation of WT1 and Rho-family GTPases.Nature communications · 2019Article
- Neural crest streaming as an emergent property of tissue interactions during morphogenesis.PLoS computational biology · 2019Article
- Stability and Roughness of Interfaces in Mechanically Regulated Tissues.Physical review letters · 2018Article
- Fingering instabilities in tissue invasion: an active fluid model.Royal Society open science · 2018Article
- Mechanical interactions among followers determine the emergence of leaders in migrating epithelial cell collectives.Nature communications · 2018Article
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Collective cell migration is of great significance in many biological processes. The goal of this work is to give a physical model for the dynamics of cell migration during the wound healing response. Experiments demonstrate that an initially uniform cell-culture monolayer expands in a nonuniform manner, developing fingerlike shapes. These fingerlike shapes of the cell culture front are composed of columns of cells that move collectively. We propose a physical model to explain this phenomenon, based on the notion of dynamic instability. In this model, we treat the first layers of cells at the front of the moving cell culture as a continuous one-dimensional membrane (contour), with the usual elasticity of a membrane: curvature and surface-tension. This membrane is active, due to the forces of cellular motility of the cells, and we propose that this motility is related to the local curvature of the culture interface; larger convex curvature correlates with a stronger cellular motility force. This shape-force relation gives rise to a dynamic instability, which we then compare to the patterns observed in the wound healing experiments.
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