ArticleJournal of cellular and molecular medicine2009
Stimulation of protein kinase C-alpha suppresses colon cancer cell proliferation by down-regulation of beta-catenin.
Article in Journal of cellular and molecular medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- PKCActa pharmaceutica Sinica. B · 2024Article
- Protein Kinase C at the Crossroad of Mutations, Cancer, Targeted Therapy and Immune Response.Biology · 2023Review
- Protein Kinase C (PKC) Isozymes as Diagnostic and Prognostic Biomarkers and Therapeutic Targets for Cancer.Cancers · 2022Review
- Root Bark ofJournal of microbiology and biotechnology · 2021Article
- The complexities of PKCα signaling in cancer.Advances in biological regulation · 2021Review
- Cytotoxic Activity of Aplykurodin A Isolated FromMarine drugs · 2020Article
- Article
- Hyperglycemia promotes microvillus membrane expression of DMT1 in intestinal epithelial cells in a PKCα-dependent manner.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Tumor promoter TPA activates Wnt/β-catenin signaling in a casein kinase 1-dependent manner.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Article
- Protein kinase C ϵ stabilizes β-catenin and regulates its subcellular localization in podocytes.The Journal of biological chemistry · 2017Article
- Low expression of PKCα and high expression of KRAS predict poor prognosis in patients with colorectal cancer.Oncology letters · 2016Article
- Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival.Oncotarget · 2016Article
- Article
- Review
- Transcriptional activation of PRMT5 by NF-Y is required for cell growth and negatively regulated by the PKC/c-Fos signaling in prostate cancer cells.Biochimica et biophysica acta · 2014Article
- Protein kinase Cα (PKCα) regulates bone architecture and osteoblast activity.The Journal of biological chemistry · 2014Article
- 2-Hydroxyoleate, a nontoxic membrane binding anticancer drug, induces glioma cell differentiation and autophagy.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Protein kinase C signaling and cell cycle regulation.Frontiers in immunology · 2012Article
- Small molecule-based promotion of PKCα-mediated β-catenin degradation suppresses the proliferation of CRT-positive cancer cells.PloS one · 2012Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We reported previously that protein kinase C-alpha (PKC-alpha) negatively regulates Wnt/beta-catenin signalling pathway. The current study explores the role of PKC-alpha in the regulation of proliferation of colon cancer cells, which contain aberrant up-regulation of intracellular beta-catenin. In colon tissue and cells, an inverse correlation was observed between the expression levels of PKC-alpha and intracellular beta-catenin. Activation of PKC-alpha inhibited beta-catenin response transcription by down-regulation of intracellular beta-catenin and induced phosphorylation of the N-terminal serine and threonine residues (Ser33/Ser37/Thr41) of beta-catenin, marking it for proteasomal degradation, in colon cancer cells. Pharmacological inhibition or depletion of PKC-alpha-abrogated PKC-alpha-mediated beta-catenin down-regulation and phosphorylation in colon cancer cells. Notably, the Ser45 residue of beta-catenin was essential for PKC-alpha-induced beta-catenin down-regulation in colon cancer cells. Moreover, PKC-alpha activation repressed the expression of cyclin D1 and c-myc, which are known beta-catenin target genes, and thus inhibited the growth of colon cancer cells. These findings suggest that PKC-alpha negatively regulates colon cancer cell proliferation viabeta-catenin phosphorylation/down-regulation and may facilitate the development of new strategies to treatment of colon cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.