ArticleThe journal of sexual medicine2010
Ontogenetic profile of the expression of thyroid hormone receptors in rat and human corpora cavernosa of the penis.
Article in The journal of sexual medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 42 citations in OpenAlex.
- Endocrine-metabolic crosstalk in erectile dysfunction: mechanistic insights and therapeutic implications.International journal of impotence research · 2026Review
- Article
- The Italian Society of Andrology and Sexual Medicine (SIAMS), along with ten other Italian Scientific Societies, guidelines on the diagnosis and management of erectile dysfunction.Journal of endocrinological investigation · 2023Article
- Is There a Role for Levo-Thyroxine for the Treatment of Arterial Erectile Dysfunction? The Clinical Relevance of the Mean Platelet Volume.Journal of clinical medicine · 2020Article
- Gender difference and correlation between sexuality, thyroid hormones, cognitive, and physical functions in elderly fit.Journal of endocrinological investigation · 2019Article
- Longer trinucleotide repeats of androgen receptor are associated with higher testosterone and low oxytocin levels in diabetic premature ejaculatory dysfunction patients.Basic and clinical andrology · 2018Article
- Premature ejaculation: challenging new and the old concepts.F1000Research · 2017Review
- Epidemiology of delayed ejaculation.Translational andrology and urology · 2016Review
- Hormonal correlations of premature ejaculation.Endocrine · 2015Review
- An Update of the International Society of Sexual Medicine's Guidelines for the Diagnosis and Treatment of Premature Ejaculation (PE).Sexual medicine · 2014Review
- Dapoxetine and the treatment of premature ejaculation.Translational andrology and urology · 2013Review
- The hormonal control of ejaculation.Nature reviews. Urology · 2012Review
- Hyperthyroidism and erectile dysfunction: a population-based case-control study.International journal of impotence researchArticle
- The association between subclinical hypothyroidism and erectile dysfunction.Pakistan journal of medical sciencesArticle
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIn the last few years, various studies have underlined a correlation between thyroid function and male sexual function, hypothesizing a direct action of thyroid hormones on the penis.
aimTo study the spatiotemporal distribution of mRNA for the thyroid hormone nuclear receptors (TR) alpha1, alpha2 and beta in the penis and smooth muscle cells (SMCs) of the corpora cavernosa of rats and humans during development.
methodsWe used several molecular biology techniques to study the TR expression in whole tissues or primary cultures from human and rodent penile tissues of different ages.
main outcome measureWe measured our data by semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) amplification, Northern blot and immunohistochemistry.
resultsWe found that TRalpha1 and TRalpha2 are both expressed in the penis and in SMCs during ontogenesis without development-dependent changes. However, in the rodent model, TRbeta shows an increase from 3 to 6 days post natum (dpn) to 20 dpn, remaining high in adulthood. The same expression profile was observed in humans. While the expression of TRbeta is strictly regulated by development, TRalpha1 is the principal isoform present in corpora cavernosa, suggesting its importance in SMC function. These results have been confirmed by immunohistochemistry localization in SMCs and endothelial cells of the corpora cavernosa.
conclusionsThe presence of TRs in the penis provides the biological basis for the direct action of thyroid hormones on this organ. Given this evidence, physicians would be advised to investigate sexual function in men with thyroid disorders.
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