ArticleOmics : a journal of integrative biology2010
Ginkgo biloba extract induces gene expression changes in xenobiotics metabolism and the Myc-centered network.
Article in Omics : a journal of integrative biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 45 citations in OpenAlex.
- Using omics approaches to dissect the therapeutic effects of Chinese herbal medicines on gastrointestinal cancers.Frontiers in pharmacology · 2022Review
- Review
- How similar is similar enough? A sufficient similarity case study with Ginkgo biloba extract.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2018Article
- Extract of Ginkgo biloba exacerbates liver metastasis in a mouse colon cancer Xenograft model.BMC complementary and alternative medicine · 2017Article
- Review of Ginkgo biloba-induced toxicity, from experimental studies to human case reports.Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews · 2017Review
- The role of CYP 3A4 and 1A1 in amiodarone-induced hepatocellular toxicity.Toxicology letters · 2016Article
- Sertraline induces endoplasmic reticulum stress in hepatic cells.Toxicology · 2014Article
- Toxicity and carcinogenicity studies of Ginkgo biloba extract in rat and mouse: liver, thyroid, and nose are targets.Toxicologic pathology · 2014Article
- Mechanistic evaluation of Ginkgo biloba leaf extract-induced genotoxicity in L5178Y cells.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- In-silico studies in Chinese herbal medicines' research: evaluation of in-silico methodologies and phytochemical data sources, and a review of research to date.Journal of ethnopharmacology · 2012Review
- Two-year toxicity and carcinogenicity studies of Panax ginseng in Fischer 344 rats and B6C3F1 mice.The American journal of Chinese medicine · 2011Article
- Gene expression profiling as an initial approach for mechanistic studies of toxicity and tumorigenicity of herbal plants and herbal dietary supplements.Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews · 2010Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The use of herbal dietary supplements in the United States is rapidly growing, and it is crucial that the quality and safety of these preparations be ensured. To date, it is still a challenge to determine the mechanisms of toxicity induced by mixtures containing many chemical components, such as herbal dietary supplements. We previously proposed that analyses of the gene expression profiles using microarrays in the livers of rodents treated with herbal dietary supplements is a potentially practical approach for understanding the mechanism of toxicity. In this study, we utilized microarrays to analyze gene expression changes in the livers of male B6C3F1 mice administered Ginkgo biloba leaf extract (GBE) by gavage for 2 years, and to determine pathways and mechanisms associated with GBE treatments. Analysis of 31,802 genes revealed that there were 129, 289, and 2,011 genes significantly changed in the 200, 600, and 2,000 mg/kg treatment groups, respectively, when compared with control animals. Drug metabolizing genes were significantly altered in response to GBE treatments. Pathway and network analyses were applied to investigate the gene relationships, functional clustering, and mechanisms involved in GBE exposure. These analyses indicate alteration in the expression of genes coding for drug metabolizing enzymes, the NRF2-mediated oxidative stress response pathway, and the Myc gene-centered network named "cell cycle, cellular movement, and cancer" were found. These results indicate that Ginkgo biloba-related drug metabolizing enzymes may cause herb-drug interactions and contribute to hepatotoxicity. In addition, the outcomes of pathway and network analysis may be used to elucidate the toxic mechanisms of Ginkgo biloba.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.