Evidence map›Paper›PMID 20141328›Full record

ArticleOmics : a journal of integrative biology2010

A persistent and diverse airway microbiota present during chronic obstructive pulmonary disease exacerbations.

Yvonne J Huang, Eugenia Kim, Michael J Cox, Eoin L Brodie, Ron Brown, Jeanine P Wiener-Kronish, Susan V Lynch

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Omics : a journal of integrative biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 145 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
145citing papers in PubMed, 7 pooled it
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

145 citing papers in PubMed, 7 syntheses or guidelines pooled it, 242 citations in OpenAlex.

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  11. Establishment of anmSystems · 2026
    Article
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  17. Macrophages and the microbiome in chronic obstructive pulmonary disease.European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
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  20. Article

85 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Yvonne J HuangDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of California San Francisco, San Francisco, California 94143-0538, USA.
Eugenia Kim
Michael J Cox
Eoin L Brodie
Ron Brown
Jeanine P Wiener-Kronish
Susan V Lynch
University of California, San Francisco · USLawrence Berkeley National Laboratory · USMassachusetts General Hospital · US

Funding

Resequencing microarray for rapid detection & antimicrobial resistance profilingU01AI075410 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LYNCH, SUSAN VERONICA · 2007 to 2011
$3.5M
NIAID NIH HHS AI075410
6 · The paper itself

Abstract

Acute exacerbations of chronic obstructive pulmonary disease (COPD) are a major source of morbidity and contribute significantly to healthcare costs. Although bacterial infections are implicated in nearly 50% of exacerbations, only a handful of pathogens have been consistently identified in COPD airways, primarily by culture-based methods, and the bacterial microbiota in acute exacerbations remains largely uncharacterized. The aim of this study was to comprehensively profile airway bacterial communities using a culture-independent microarray, the 16S rRNA PhyloChip, of a cohort of COPD patients requiring ventilatory support and antibiotic therapy for exacerbation-related respiratory failure. PhyloChip analysis revealed the presence of over 1,200 bacterial taxa representing 140 distinct families, many previously undetected in airway diseases; bacterial community composition was strongly influenced by the duration of intubation. A core community of 75 taxa was detected in all patients, many of which are known pathogens. Bacterial community diversity in COPD airways is substantially greater than previously recognized and includes a number of potential pathogens detected in the setting of antibiotic exposure. Comprehensive assessment of the COPD airway microbiota using high-throughput, culture-independent methods may prove key to understanding the relationships between airway bacterial colonization, acute exacerbation, and clinical outcomes in this and other chronic inflammatory airway diseases.

Indexed as

AgedAged, 80 and overBacteriaBase SequenceBronchiBronchoalveolar Lavage FluidCohort StudiesDNA PrimersFemaleHumansMaleMiddle AgedPhylogenyPolymerase Chain ReactionPulmonary Disease, Chronic ObstructiveRNA, Ribosomal, 16SDNA PrimersRNA, Ribosomal, 16S

Identifiers

PMID20141328
PMCPMC3116451
OpenAlexW2006860411

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.