SynthesisHerz2010
Congenital heart disease in pregnancies complicated by maternal diabetes mellitus. An international clinical collaboration, literature review, and meta-analysis.
Synthesis in Herz, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
79 citing papers in PubMed, 4 syntheses or guidelines pooled it, 180 citations in OpenAlex.
- Effect of maternal diabetes on fetal heart function on echocardiography: systematic review and meta-analysis.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2021Pooled it
- Establishment of Relational Model of Congenital Heart Disease Markers and GO Functional Analysis of the Association between Its Serum Markers and Susceptibility Genes.Computational and mathematical methods in medicine · 2016Pooled it
- Diabetes and congenital heart defects: a systematic review, meta-analysis, and modeling project.American journal of preventive medicine · 2015Pooled it
- Maternal socioeconomic status and the risk of congenital heart defects in offspring: a meta-analysis of 33 studies.PloS one · 2014Pooled it
- The Impact of Maternal Obesity and Diabetes on the Development of Congenital Heart Defects (CHDs) in Offspring: A Narrative Review.Metabolites · 2026Review
- Prenatal and Maternal Contributors to Disease Severity in Congenital Heart Disease.Maternal and child health journal · 2026Article
- Advances in interdisciplinary care for term and preterm neonates with congenital heart disease: a narrative review.European journal of pediatrics · 2026Review
- Risk assessment of congenital heart defects based on maternal factors in early pregnancy-a systematic review and meta-analysis.Frontiers of medicine · 2025Review
- Article
- Fetal Interventricular Septum Volume Evaluated by Four-Dimensional Ultrasound Using Spatiotemporal Image Correlation (STIC) and Virtual Organ Computer-Aided Analysis (VOCAL) in Fetuses from Gestational Diabetes Mellitus Pregnant Women Compared to Fetuses from Healthy Pregnant Women.International journal of women's health · 2025Article
- Effects of Gestational Diabetes Mellitus on Fetal Cardiac Morphology.Medical sciences (Basel, Switzerland) · 2024Article
- Maternal periconception hyperglycemia, preconception diabetes, and risk of major congenital malformations in offspring.Human reproduction (Oxford, England) · 2024Article
- Article
- Referral pattern of pregnant mother for fetal echocardiography in Shiraz, South Iran.BMC cardiovascular disorders · 2024Article
- Comorbidity patterns in cardiovascular diseases: the role of life-stage and socioeconomic status.Frontiers in cardiovascular medicine · 2024Article
- Human Genetics of d-Transposition of Great Arteries.Advances in experimental medicine and biology · 2024Review
- Quantifying fetal heart health in gestational diabetes: a new approach with fetal heart quantification technology.Frontiers in pharmacology · 2024Article
- Proteome profiling of early gestational plasma reveals novel biomarkers of congenital heart disease.EMBO molecular medicine · 2023Article
- Maternal Pre-Existing Diabetes: A Non-Inherited Risk Factor for Congenital Cardiopathies.International journal of molecular sciences · 2023Review
- Fetal echocardiography changes of the right ventricle of well-controlled gestational diabetes mellitus.BMC cardiovascular disorders · 2023Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeInvestigation of the incidence and distribution of congenital structural cardiac malformations among the offspring of mothers with diabetes type 1 and of the influence of periconceptional glycemic control.
methodsMulticenter retrospective clinical study, literature review, and meta-analysis. The incidence and pattern of congenital heart disease in the own study population and in the literature on the offspring of type 1 diabetic mothers were compared with the incidence and spectrum of the various cardiovascular defects in the offspring of nondiabetic mothers as registered by EUROCAT Northern Netherlands. Medical records were, in addition, reviewed for HbA(1c) during the 1st trimester.
resultsThe distribution of congenital heart anomalies in the own diabetic study population was in accordance with the distribution encountered in the literature. This distribution differed considerably from that in the nondiabetic population. Approximately half the cardiovascular defects were conotruncal anomalies. The authors' study demonstrated a remarkable increase in the likelihood of visceral heterotaxia and variants of single ventricle among these patients. As expected, elevated HbA(1c) values during the 1st trimester were associated with offspring fetal cardiovascular defects.
conclusionThis study shows an increased likelihood of specific heart anomalies, namely transposition of the great arteries, persistent truncus arteriosus, visceral heterotaxia and single ventricle, among offspring of diabetic mothers. This suggests a profound teratogenic effect at a very early stage in cardiogenesis. The study emphasizes the frequency with which the offspring of diabetes-complicated pregnancies suffer from complex forms of congenital heart disease. Pregnancies with poor 1st-trimester glycemic control are more prone to the presence of fetal heart disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.