ArticleMolecular biology reports2011
Polymorphisms in the bovine ghrelin precursor (GHRL) and Syndecan-1 (SDC1) genes that are associated with growth traits in cattle.
Article in Molecular biology reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 24 citations in OpenAlex.
- Syndecans modulate ghrelin receptor signaling.Journal of molecular endocrinology · 2025Article
- Taurine and Indicine Haplotype Representation in Advanced Generation Individuals From Three American Breeds.Frontiers in genetics · 2021Article
- Article
- MALDI-TOF-MS-based high throughput genotyping of mutations associated with body measurement traits in cattle.Mammalian genome : official journal of the International Mammalian Genome Society · 2020Article
- Article
- Association of Ghrelin Gene Polymorphisms with Fattening Traits and Feed Intake in Pig: A Preliminary Study.Animals : an open access journal from MDPI · 2019Article
- MUC1 gene polymorphism in three Nelore lines selected for growth and its association with growth and carcass traits.Molecular biology reports · 2012Article
- Association analysis of polymorphisms of porcine LMP2 and LMP7 genes with haematological traits.Molecular biology reports · 2011Article
- Novel polymorphisms of goat growth hormone and growth hormone receptor genes and their effects on growth traits.Molecular biology reports · 2011Article
- A novel SNP of the ATP1A1 gene is associated with heat tolerance traits in dairy cows.Molecular biology reports · 2011Article
- Characterization of the GHR gene genetic variation in Chinese indigenous goat breeds.Molecular biology reports · 2011Article
- Effects of genetic variability of the dairy goat growth hormone releasing hormone receptor (GHRHR) gene on growth traits.Molecular biology reports · 2011Article
- Molecular characterization, polymorphism of bovine ZBTB38 gene and association with body measurement traits in native Chinese cattle breeds.Molecular biology reports · 2010Article
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Authors and funding
8 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Transgenically expressed Syndecan-1 was found in the hypothalamic nuclei that control energy balance, and was associated with maturity-onset obesity, while ghrelin has been shown to play important roles in the control of food intake, gastric acid secretion, energy homeostasis, and glucose and lipid metabolism. However, the roles of genetic variations of Syndecan-1 and ghrelin on growth trait have few been reported in cattle. Herein, five Chinese cattle breeds were analyzed by PCR-SSCP and DNA sequencing methods. The bovine ghrelin gene showed eleven SNPs g.[267G>A, 271G>A, 290C>T, 326A>G, 327T>C, 420C>A, 569A>G, 945C>T, 993C>T, 4491A>G, 4644G>A] and three SNPs g.[420C>A, 569 A>G, 945C>T] were firstly detected in cattle. The bovine Syndecan-1 gene showed two SNPs. One SNP showed a transition C>G at position 21514, resulting in a synonymous mutation p.G(GGC)169G(GGG) and another showed a transversion C>T at position 22591, resulting in a synonymous mutation p.D(GAC)283D(GAT). In ghrelin gene, no significant associations were revealed between any variant sites and body weight, average daily gain, body sizes for different growth periods (6, 12, 18, and 24 months old), as well as for the milk yield at 305 days, milk protein rate and milk fat percentage. However, the polymorphism of Syndecan-1 gene was significantly associated with bovine birth weight and body length. Hence, we first suggested that Syndecan-1 gene could be regarded as molecular marker for superior birth weight and body length.
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