ArticleMolecular biology reports2011
Characterization of microRNAs from sheep (Ovis aries) using computational and experimental analyses.
Article in Molecular biology reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 34 citations in OpenAlex.
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- Identification of microRNA Transcriptome Involved in Bovine Intramuscular Fat Deposition.Frontiers in veterinary science · 2022Article
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- Localized expression and inhibition effect of miR-184 on blood digestion and oviposition in Haemaphysalis longicornis (Acari: Ixodidae).Parasites & vectors · 2019Article
- Identification and comparison of microRNAs in pituitary gland during prenatal and postnatal stages of sheep by deep sequencing.Journal of genetics · 2018Article
- Shifts in ovine cardiopulmonary microRNA expression in late gestation and the perinatal period.PloS one · 2018Article
- Computational prediction of candidate miRNAs and their potential functions in biomineralization in pearl oyster Pinctada martensii.Saudi journal of biological sciences · 2016Article
- Identification and characterization of microRNAs in Eucheuma denticulatum by high-throughput sequencing and bioinformatics analysis.RNA biology · 2016Article
- Comparative genomic approach reveals novel conserved microRNAs in Inner Mongolia cashmere goat skin and longissimus dorsi.Molecular biology reports · 2015Article
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- Computational Identification of MicroRNAs from the Expressed Sequence Tags of Toxic Dinoflagellate Alexandrium Tamarense.Evolutionary bioinformatics online · 2013Article
- The MicroRNAs and their targets in the channel catfish (Ictalurus punctatus).Molecular biology reports · 2012Article
- The novel 172 sheep (Ovis aries) microRNAs and their targets.Molecular biology reports · 2012Article
- Generation and analysis of expressed sequence tags from the bone marrow of Chinese Sika deer.Molecular biology reports · 2012Article
- Biological role of microRNA-103 based on expression profile and target genes analysis in pigs.Molecular biology reports · 2011Article
- Molecular cloning, sequence identification and tissue expression profile of three novel genes Sfxn1, Snai2 and Cno from Black-boned sheep (Ovis aries).Molecular biology reports · 2011Article
- Tobacco microRNAs prediction and their expression infected with Cucumber mosaic virus and Potato virus X.Molecular biology reports · 2011Article
- Localized expression pattern of miR-184 in Drosophila.Molecular biology reports · 2011Article
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Authors and funding
10 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ovis aries is one of the most important agricultural livestock for meat production, and also is an ideal model organism for biological and comparative genomics studies. Many miRNAs have been reported for their important roles in developmental processes in various animals, but there is limited information about O. aries miRNAs. In this study, combining a computational method based on expressed sequence tag (EST) analysis with experimental identification based on small RNA cDNA library, we identified 31 miRNAs belong to 24 families in sheep, 2 of which were novel miRNAs which had never been previously identified in any species. Especially, we cloned 12 miRNAs from the sheep skeletal muscle, which were good candidate miRNAs to be studied about the miRNA-dependant regulated process of muscle development, and we identified four pairs of miRNA/miRNA and one pair of miRNA-3p/miRNA-5p from sheep EST sequences. Expression analysis indicated that some miRNAs were expressed in a specific tissue, and the pair of miRNA-3p/miRNA-5p and one pair of miRNA/miRNA had a similar relative expression pattern in some tissues, respectively. Further, we predicted 120 potential target genes of 31 oar-miRNAs on the 3'UTR of O. aries genes. Gene ontology analysis showed that most of these genes took part in the cellular process and metabolic process. Our results enriched the O. aries miRNA database and provided useful information for investigating biological functions of miRNAs and miRNA in sheep.
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