ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2010
Postnatal development of muscle biochemistry in nursing harbor seal (Phoca vitulina) pups: limitations to diving behavior?
Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 38 citations in OpenAlex.
- Breath-hold capacities and circadian dive rhythmicity shape optimal foraging strategies in a polar marine mammal, the Weddell seal (Leptonychotes weddellii).Communications biology · 2024Article
- The benthic-pelagic continuum: Age class and sex differences in the use of the vertical dimension by a rare pinniped.Ecology and evolution · 2023Article
- Iron mobilization during lactation reduces oxygen stores in a diving mammal.Nature communications · 2022Article
- Environmental drivers of population-level variation in the migratory and diving ontogeny of an Arctic top predator.Royal Society open science · 2022Article
- microRNA profiling in the Weddell seal suggests novel regulatory mechanisms contributing to diving adaptation.BMC genomics · 2020Article
- Links between muscle phenotype and life history: differentiation of myosin heavy chain composition and muscle biochemistry in precocial and altricial pinniped pups.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2019Article
- Low guanylyl cyclase activity in Weddell seals: implications for peripheral vasoconstriction and perfusion of the brain during diving.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Article
- Scaling matters: incorporating body composition into Weddell seal seasonal oxygen store comparisons reveals maintenance of aerobic capacities.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2015Article
- The degradation of proteins in pinniped skeletal muscle: viability of post-mortem tissue in physiological research.Conservation physiology · 2015Article
- A review of the multi-level adaptations for maximizing aerobic dive duration in marine mammals: from biochemistry to behavior.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2014Review
- Dynamics of Vibrio with virulence genes detected in Pacific harbor seals (Phoca vitulina richardii) off California: implications for marine mammal health.Microbial ecology · 2013Article
- Article
- Development of the aerobic dive limit and muscular efficiency in northern fur seals (Callorhinus ursinus).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2012Article
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adult marine mammal muscles rely upon a suite of adaptations for sustained aerobic metabolism in the absence of freely available oxygen (O(2)). Although the importance of these adaptations for supporting aerobic diving patterns of adults is well understood, little is known about postnatal muscle development in young marine mammals. However, the typical pattern of vertebrate muscle development, and reduced tissue O(2) stores and diving ability of young marine mammals suggest that the physiological properties of harbor seal (Phoca vitulina) pup muscle will differ from those of adults. We examined myoglobin (Mb) concentration, and the activities of citrate synthase (CS), beta-hydroxyacyl coA dehydrogenase (HOAD), and lactate dehydrogenase (LDH) in muscle biopsies from harbor seal pups throughout the nursing period, and compared these biochemical parameters to those of adults. Pups had reduced O(2) carrying capacity ([Mb] 28-41% lower than adults) and reduced metabolically scaled catabolic enzyme activities (LDH/RMR 20-58% and CS/RMR 29-89% lower than adults), indicating that harbor seal pup muscles are biochemically immature at birth and weaning. This suggests that pup muscles do not have the ability to support either the aerobic or anaerobic performance of adult seals. This immaturity may contribute to the lower diving capacity and behavior in younger pups. In addition, the trends in myoglobin concentration and enzyme activity seen in this study appear to be developmental and/or exercise-driven responses that together work to produce the hypoxic endurance phenotype seen in adults, rather than allometric effects due to body size.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.