ArticleNeurosurgical review2010
Patient selection for revascularization procedures in adult Moyamoya disease based on dynamic perfusion computerized tomography with acetazolamide challenge (PCTA).
Article in Neurosurgical review, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 19 citations in OpenAlex.
- High Intravascular Signal Arterial Transit Time Artifacts Have Negligible Effects on Cerebral Blood Flow and Cerebrovascular Reserve Capacity Measurement Using Single Postlabel Delay Arterial Spin-Labeling in Patients with Moyamoya Disease.AJNR. American journal of neuroradiology · 2020Article
- What and why: the current situation and future prospects of "ivy sign" in moyamoya disease.Therapeutic advances in chronic disease · 2020Review
- Neural Correlates of Motor Recovery Measured by SPECT at Six Months After Basal Ganglia Stroke.Annals of rehabilitation medicine · 2017Article
- Article
- Changes in computed tomography perfusion parameters after superficial temporal artery to middle cerebral artery bypass: an analysis of 29 cases.Journal of neurological surgery. Part B, Skull base · 2014Article
- "Imaging Evaluation of Collaterals in the Brain: Physiology and Clinical Translation"Current radiology reports · 2014Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The usefulness of dynamic perfusion computerized tomography for early diagnosis of stroke is well established. However, limited data exists to assess the value of PCT in the evaluation of patients with chronic cerebral ischemia. The purpose of the study was to assess the utility of perfusion computerized tomography with acetazolamide challenge (PCTA) in the evaluation of cerebral perfusion and cerebrovascular reserve (CVR) in adult Moyamoya patients. From 2005-2008, 41 patients with Moyamoya were scrutinized by PCTA. Of these, 22 patients (12 females, ten males, mean age 41 years) with ischemic symptoms from Moyamoya disease were found to have no response or decreased cerebrovascular flow post-acetazolamide indicating compromised CVR. Eight had bilateral symptoms. Based on matching symptoms and decreased CVR on PCTA, those 22 patients underwent 30 superficial temporal artery-to-middle cerebral artery (STA-MCA) by-pass (eight with bilateral abnormal PCTA had bilateral STA-MCA by-pass). After a mean follow-up of 14 months (range, 3-36 months), no new strokes or symptoms were reported. Graft patency, as documented by postoperative computerized tomography angiography at a mean 12 weeks after surgery was 100%. Eight patients had postoperative PCTA documenting improved CVR after STA-MCA by-pass. At latest follow-up, none of the 19 patients with PCTA findings suggestive of normal CVR had any ischemic symptoms. CVR testing by means of PCTA may have a key role in patient selection for revascularization surgery and postoperative follow-up. These promising results warrant further testing of the technique.
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