ArticleCellular and molecular neurobiology2010
Dopaminergic modulation of spiny neurons in the turtle striatum.
Article in Cellular and molecular neurobiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- On and Off switches in the brain.Frontiers in behavioral neuroscience · 2015Article
- Dopamine differentially modulates the excitability of striatal neurons of the direct and indirect pathways in lamprey.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Evolutionarily conserved differences in pallial and thalamic short-term synaptic plasticity in striatum.The Journal of physiology · 2013Article
- The dopamine D2 receptor gene in lamprey, its expression in the striatum and cellular effects of D2 receptor activation.PloS one · 2012Article
- Striatal cellular properties conserved from lampreys to mammals.The Journal of physiology · 2011Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracellular recordings were obtained from brain slice preparation in neurons of the striatum of the turtle Trachemys scripta elegans, analogous to the mammalian striatum in its topographic organization, synaptic connectivity, cytoarchitecture, and neurochemistry. Here we show that these similarities extend to the electrophysiological properties of its neurons. Biocytin staining revealed that 85% of the recorded neurons were medium spiny neurons while 15% were aspiny neurons. Spiny neurons of the turtle resembled those found in the mammalian and avian striatum and express dopaminergic D(1) and D(2) class receptors. Because the striatum of the turtle receives a dense dopaminergic innervation from tegmental dopaminergic neurons we investigated the postsynaptic actions of selective dopamine receptor agonists in the excitability of spiny neurons. As in mammals and birds, activation of D(1)-receptors enhances, whereas activation of D(2)-receptors decreases the evoked discharge. Apparently, actions of dopamine agonists occur via the modulation of L-type (Ca(V)1) Ca2+-conductances. Strong cellular evidence suggests that the role of dopamine in the modulation of motor networks is preserved along vertebrate evolution.
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