Evidence map›Paper›PMID 20140250›Full record

Trial reportPloS one2010

Effect of a high intake of conjugated linoleic acid on lipoprotein levels in healthy human subjects.

Anne J Wanders, Ingeborg A Brouwer, Els Siebelink, Martijn B Katan

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 27 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 4 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00529828 nacompletednot on this map

Health Effects of CLA Versus Industrial Trans Fatty Acids in Healthy Volunteers (CLARINeT-Study)

TypeinterventionalSponsorWageningen UniversityRan2007 to 2008Enrolled60ConditionsHealthyArmsConsumption of CLA enriched food
NCT02529046 nacompletednot on this map

Effect of Conjugated Linoleic Acid Associated With Aerobic Exercise on Body Fat and Lipid Profile in Obese Women: A Randomized, Double-blinded and Placebo-controlled Trial

TypeinterventionalSponsorUniversidade Estadual de LondrinaRan2007 to 2007Enrolled28ConditionsLipid Metabolism Disorders, ObesityArmsCLA, Placebo
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 4 syntheses or guidelines pooled it, 105 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. Pooled it
  5. Trial
  6. Trial
  7. Review
  8. Article
  9. Article
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  11. Article
  12. Review
  13. Molecules (Basel, Switzerland) · 2020
    Article
  14. Review
  15. Observational
  16. Article
  17. Metabolic and Biochemical Stressors in Diabetic Cardiomyopathy.Frontiers in cardiovascular medicine · 2017
    Review
  18. Review
  19. Review
  20. Trans fatty acids - A risk factor for cardiovascular disease.Pakistan journal of medical sciences · 2014
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Anne J WandersDepartment of Health Sciences and the EMGO Institute for Health Care Research, VU University Amsterdam, Amsterdam, The Netherlands.
Ingeborg A Brouwer
Els Siebelink
Martijn B Katan
Wageningen University & Research · NLEMGO Institute for Health and Care Research · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTrans fatty acids are produced either by industrial hydrogenation or by biohydrogenation in the rumens of cows and sheep. Industrial trans fatty acids lower high-density lipoprotein (HDL) cholesterol, raise low-density lipoprotein (LDL) cholesterol, and increase the risk of coronary heart disease. The effects of trans fatty acids from ruminants are less clear. We investigated the effect on blood lipids of cis-9, trans-11 conjugated linoleic acid (CLA), a trans fatty acid largely restricted to ruminant fats. METHODOLOGY/PRINCIPAL

findingsSixty-one healthy women and men were sequentially fed each of three diets for three weeks, in random order, for a total of nine weeks. Diets were identical except for 7% of energy (approximately 20 g/day), which was provided either by oleic acid, by industrial trans fatty acids, or by a mixture of 80% cis-9, trans-11 and 20% trans-10, cis-12 CLA. After the oleic acid diet, mean (+/- SD) serum LDL cholesterol was 2.68+/-0.62 mmol/L compared to 3.00+/-0.66 mmol/L after industrial trans fatty acids (p<0.001), and 2.92+/-0.70 mmol/L after CLA (p<0.001). Compared to oleic acid, HDL-cholesterol was 0.05+/-0.12 mmol/L lower after industrial trans fatty acids (p = 0.001) and 0.06+/-0.10 mmol/L lower after CLA (p<0.001). The total-to-HDL cholesterol ratio was 11.6% higher after industrial trans fatty acids (p<0.001) and 10.0% higher after CLA (p<0.001) relative to the oleic acid diet. CONCLUSIONS/SIGNIFICANCE: High intakes of an 80:20 mixture of cis-9, trans-11 and trans-10, cis-12 CLA raise the total to HDL cholesterol ratio in healthy volunteers. The effect of CLA may be somewhat less than that of industrial trans fatty acids.

trial registrationClinicalTrials.gov NCT00529828.

Indexed as

AdolescentAdultApolipoproteins BBody WeightCholesterol, HDLCholesterol, LDLCross-Over StudiesDiarrheaDietary FatsFemaleHumansLinoleic Acids, ConjugatedLipidsMaleMiddle AgedNauseaApolipoproteins BCholesterol, HDLCholesterol, LDLDietary FatsLinoleic Acids, ConjugatedLipids

Identifiers

PMID20140250
PMCPMC2815780
OpenAlexW2116813969

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.