ArticlePloS one2010
CpG methylation of a silent controlling element in the murine Avy allele is incomplete and unresponsive to methyl donor supplementation.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Epigenetics Research in Evolutionary Biology: Perspectives on Timescales and Mechanisms.Molecular biology and evolution · 2024Review
- The Contribution of Epigenetic Inheritance Processes on Age-Related Cognitive Decline and Alzheimer's Disease.Epigenomes · 2021Review
- Epigenetics of the developing and aging brain: Mechanisms that regulate onset and outcomes of brain reorganization.Neuroscience and biobehavioral reviews · 2021Review
- Effects of post-weaning diet on metabolic parameters and DNA methylation status of the cryptic promoter in the A(vy) allele of viable yellow mice.The Journal of nutritional biochemistry · 2015Article
- Stochastic developmental variation, an epigenetic source of phenotypic diversity with far-reaching biological consequences.Journal of biosciences · 2015Review
- Metabolism and epigenetics.Annual review of cell and developmental biology · 2015Review
- DNA methylation is dispensable for suppression of the agouti viable yellow controlling element in murine embryonic stem cells.PloS one · 2014Article
- How do mammalian transposons induce genetic variation? A conceptual framework: the age, structure, allele frequency, and genome context of transposable elements may define their wide-ranging biological impacts.BioEssays : news and reviews in molecular, cellular and developmental biology · 2013Article
- Maternal exposure to bisphenol A and genistein has minimal effect on A(vy)/a offspring coat color but favors birth of agouti over nonagouti mice.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Methyl donor supplementation blocks the adverse effects of maternal high fat diet on offspring physiology.PloS one · 2013Article
- Micronutrient status and global DNA methylation in school-age children.Epigenetics · 2012Article
- The influence of DNA sequence on epigenome-induced pathologies.Epigenetics & chromatin · 2012Article
- The penetrance of an epigenetic trait in mice is progressively yet reversibly increased by selection and environment.Proceedings. Biological sciences · 2012Article
- Genetic and epigenomic footprints of folate.Progress in molecular biology and translational science · 2012Review
- Sensitive quantitative analysis of murine LINE1 DNA methylation using high resolution melt analysis.Epigenetics · 2012Article
- Distinct DNA methylation epigenotypes in bladder cancer from different Chinese sub-populations and its implication in cancer detection using voided urine.BMC medical genomics · 2011Article
- A sustained dietary change increases epigenetic variation in isogenic mice.PLoS genetics · 2011Article
- Epigenetic memory in mammals.Frontiers in genetics · 2011Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundThe viable yellow allele of agouti (A(vy)) is remarkable for its unstable and partially heritable epigenetic state, which produces wide variation in phenotypes of isogenic mice. In the A(vy) allele an inserted intracisternal A particle (IAP) acts as a controlling element which deregulates expression of agouti by transcription from the LTR of the IAP; the phenotypic state has been linked to CpG methylation of the LTR. Phenotypic variation between A(vy) mice indicates that the epigenetic state of the IAP is unstable in the germline. PRINCIPAL
findingsWe have made a detailed examination of somatic methylation of the IAP using bisulphite allelic sequencing, and find that the promoter is incompletely methylated even when it is transcriptionally silent. In utero exposure to supplementary methyl donors, which alters the spectrum of A(vy) phenotypes, does not increase the density of CpG methylation in the silent LTR.
conclusionsOur findings suggest that, contrary to previous supposition, methyl donor supplementation acts through an indirect mechanism to silence A(vy). The incomplete cytosine methylation we observe at the somatically silent A(vy) allele may reflect its unstable germline state, and the influence of epigenetic modifications underlying CpG methylation.
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