ArticlePLoS genetics2010
Replication and active demethylation represent partially overlapping mechanisms for erasure of H3K4me3 in budding yeast.
Article in PLoS genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- A systematic interactome ofeLife · 2026Article
- Analogue-Sensitive Inhibition of Histone Demethylases Uncovers Member-Specific Function in Ribosomal Protein Synthesis.Journal of the American Chemical Society · 2025Article
- Diverse and dynamic forms of gene regulation by the S. cerevisiae histone methyltransferase Set1.Current genetics · 2023Review
- H3 Lysine 4 Methylation Is Required for Full Activation of Genes Involved in α-Ketoglutarate Availability in the Nucleus of Yeast Cells after Diauxic Shift.Metabolites · 2023Article
- Metabolo-epigenetic interplay provides targeted nutritional interventions in chronic diseases and ageing.Frontiers in oncology · 2023Review
- Allele-Specific Chemical Rescue of Histone Demethylases Using Abiotic Cofactors.ACS chemical biology · 2022Article
- LSD1 is required for euchromatic origin firing and replication timing.Signal transduction and targeted therapy · 2022Article
- Precision Methylome and In Vivo Methylation Kinetics Characterization of Klebsiella pneumoniae.Genomics, proteomics & bioinformatics · 2022Article
- H3K4 Methylation in Aging and Metabolism.Epigenomes · 2021Review
- Allele-Specific Inhibition of Histone Demethylases.Chembiochem : a European journal of chemical biology · 2019Article
- The Set1 complex is dimeric and acts with Jhd2 demethylation to convey symmetrical H3K4 trimethylation.Genes & development · 2019Article
- The Bump-and-Hole Tactic: Expanding the Scope of Chemical Genetics.Cell chemical biology · 2018Review
- The PHD finger protein Spp1 has distinct functions in the Set1 and the meiotic DSB formation complexes.PLoS genetics · 2018Article
- Chromatin dynamics during DNA replication.Genome research · 2016Article
- A role for Rtt109 in buffering gene-dosage imbalance during DNA replication.Nucleus (Austin, Tex.) · 2016Review
- Histone demethylases in chromatin biology and beyond.EMBO reports · 2015Review
- Uncoupling histone turnover from transcription-associated histone H3 modifications.Nucleic acids research · 2015Article
- H3K4me3 demethylation by the histone demethylase KDM5C/JARID1C promotes DNA replication origin firing.Nucleic acids research · 2015Article
- Article
- Lysine acetylation controls local protein conformation by influencing proline isomerization.Molecular cell · 2014Article
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Authors and funding
5 authors.
Funding
Abstract
Histone modifications affect DNA-templated processes ranging from transcription to genomic replication. In this study, we examine the cell cycle dynamics of the trimethylated form of histone H3 lysine 4 (H3K4me3), a mark of active chromatin that is viewed as "long-lived" and that is involved in memory during cell state inheritance in metazoans. We synchronized yeast using two different protocols, then followed H3K4me3 patterns as yeast passed through subsequent cell cycles. While most H3K4me3 patterns were conserved from one generation to the next, we found that methylation patterns induced by alpha factor or high temperature were erased within one cell cycle, during S phase. Early-replicating regions were erased before late-replicating regions, implicating replication in H3K4me3 loss. However, nearly complete H3K4me3 erasure occurred at the majority of loci even when replication was prevented, suggesting that most erasure results from an active process. Indeed, deletion of the demethylase Jhd2 slowed erasure at most loci. Together, these results indicate overlapping roles for passive dilution and active enzymatic demethylation in erasing ancestral histone methylation states in yeast.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.