Evidence map›Paper›PMID 20139978›Full record

ArticleNature genetics2010

Genome-wide association study of hematological and biochemical traits in a Japanese population.

Yoichiro Kamatani, Koichi Matsuda, Yukinori Okada, Michiaki Kubo, Naoya Hosono, Yataro Daigo, Yusuke Nakamura, Naoyuki Kamatani

Abstract read
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In one paragraph

Article in Nature genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 301 papers, 24 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
301citing papers in PubMed, 24 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

301 citing papers in PubMed, 24 syntheses or guidelines pooled it.

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  2. Genome-wide meta-analysis of alcohol use disorder in East Asians.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
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241 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yoichiro KamataniLaboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, the University of Tokyo, Tokyo, Japan.
Koichi Matsuda
Yukinori Okada
Michiaki Kubo
Naoya Hosono
Yataro Daigo
Yusuke Nakamura
Naoyuki Kamatani

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report genome-wide association studies for hematological and biochemical traits from approximately 14,700 Japanese individuals. We identified 60 associations for 8 hematological traits and 29 associations for 12 biochemical traits at genome-wide significance levels (P < 5 x 10(-8)). Of these, 46 associations were new to this study and 43 replicated previous reports. We compared these associated loci with those reported in similar GWAS in European populations. When the minor allele frequency was >10% in the Japanese population, 32 (94.1%) and 31 (91.2%) of the 34 hematological loci previously reported to be associated in a European population were replicated with P-values less than 0.05 and 0.01, respectively, and 31 (73.8%) and 27 (64.3%) of the 42 European biochemical loci were replicated.

Indexed as

Genome-Wide Association StudyQuantitative Trait LociAsian PeopleBiomarkersBlood Cell CountBlood Chemical AnalysisCohort StudiesErythrocytesGene FrequencyGenetics, PopulationHematologic DiseasesHematologic TestsHumansPolymorphism, Single NucleotideUric AcidBiomarkersUric Acid

Identifiers

PMID20139978

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.