ArticleChannels (Austin, Tex.)
Changes in intra-luminal calcium during spontaneous calcium waves following sensitization of ryanodine receptor channels.
Article in Channels (Austin, Tex.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Elementary calcium signaling in arterial smooth muscle.Channels (Austin, Tex.) · 2019Review
- Obstruction of ventricular CaThe Journal of physiology · 2018Article
- Facilitation of cytosolic calcium wave propagation by local calcium uptake into the sarcoplasmic reticulum in cardiac myocytes.The Journal of physiology · 2012Article
- β-Adrenergic stimulation increases the intra-sarcoplasmic reticulum Ca2+ threshold for Ca2+ wave generation.The Journal of physiology · 2012Article
- Intercellular Ca(2+) waves: mechanisms and function.Physiological reviews · 2012Review
- Dantrolene prevents arrhythmogenic Ca2+ release in heart failure.American journal of physiology. Heart and circulatory physiology · 2012Article
- β-adrenergic stimulation increases the intra-SR Ca termination threshold for spontaneous Ca waves in cardiac myocytes.Channels (Austin, Tex.)Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Cardiac contraction during systole is dependent on action potential-triggered Ca(2+) release from the sarcoplasmic reticulum (SR) through ryanodine receptor (RyR) channels. SR Ca(2+) release can also occur spontaneously during diastole, which causes a decrease in Ca(2+) content within the SR and contributes to arrhythmogenesis. Here, we use measurements of cytosolic Ca(2+) and intra-SR Ca(2+) ([Ca(2+)](SR)) to examine how RyR sensitization alters spontaneous SR Ca(2+) release events in rabbit ventricular myocytes. RyR sensitization with caffeine (250 microM) increased the open probability of single RyR channels, increased the initial frequency and amplitude of local SR Ca(2+) release events (Ca(2+) sparks), and decreased the [Ca(2+)](SR) level where Ca(2+) sparks terminated. In intact myocytes, caffeine applied during rest after steady-state electrical stimulation increased the frequency of spontaneous Ca(2+) waves and decreased the [Ca(2+)](SR) level where waves terminated. These effects caused a marked loss of SR Ca(2+) content. Therefore, increasing RyR activity has complex effects on cardiac function. Increased RyR activity during systole is beneficial as it increases SR Ca(2+) release and contractile strength. However, increased RyR activity during diastole produces spontaneous, arrhythmogenic Ca(2+) release events that lower SR Ca(2+) content and subsequently decrease contractility.
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Registered trials
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