ArticleThe Journal of biological chemistry2010
Snf1 dependence of peroxisomal gene expression is mediated by Adr1.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 49 citations in OpenAlex.
- TOR and heat shock response pathways regulate peroxisome biogenesis during proteotoxic stress.Nature communications · 2025Article
- Mechanism of enhanced salt tolerance in Saccharomyces cerevisiae by CRZ1 overexpression.Scientific reports · 2024Article
- Tra1 controls the transcriptional landscape of the aging cell.G3 (Bethesda, Md.) · 2023Article
- Peroxisome compartmentalization of a toxic enzyme improves alkaloid production.Nature chemical biology · 2021Article
- Mitochondria-cytosol-nucleus crosstalk: learning from Saccharomyces cerevisiae.FEMS yeast research · 2018Review
- Ask yeast how to burn your fats: lessons learned from the metabolic adaptation to salt stress.Current genetics · 2018Review
- The stress-regulatory transcription factors Msn2 and Msn4 regulate fatty acid oxidation in budding yeast.The Journal of biological chemistry · 2017Article
- Mit1 Transcription Factor Mediates Methanol Signaling and Regulates the Alcohol Oxidase 1 (AOX1) Promoter in Pichia pastoris.The Journal of biological chemistry · 2016Article
- Glucose repression in Saccharomyces cerevisiae.FEMS yeast research · 2015Review
- Pichia pastoris regulates its gene-specific response to different carbon sources at the transcriptional, rather than the translational, level.BMC genomics · 2015Article
- Repression of multiple CYP2D genes in mouse primary hepatocytes with a single siRNA construct.In vitro cellular & developmental biology. Animal · 2015Article
- Yeast 14-3-3 protein functions as a comodulator of transcription by inhibiting coactivator functions.The Journal of biological chemistry · 2014Article
- Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae.FEMS microbiology reviews · 2014Review
- Molecular mechanisms of system responses to novel stimuli are predictable from public data.Nucleic acids research · 2014Article
- Crosstalk between SNF1 pathway and the peroxisome-mediated lipid metabolism in Magnaporthe oryzae.PloS one · 2014Article
- Binding and transcriptional regulation by 14-3-3 (Bmh) proteins requires residues outside of the canonical motif.Eukaryotic cell · 2014Article
- PhosphoChain: a novel algorithm to predict kinase and phosphatase networks from high-throughput expression data.Bioinformatics (Oxford, England) · 2013Article
- Nucleotide degradation and ribose salvage in yeast.Molecular systems biology · 2013Article
- 14-3-3 (Bmh) proteins regulate combinatorial transcription following RNA polymerase II recruitment by binding at Adr1-dependent promoters in Saccharomyces cerevisiae.Molecular and cellular biology · 2013Article
- Nutritional control of growth and development in yeast.Genetics · 2012Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Eukaryotes utilize fatty acids by beta-oxidation, which occurs in the mitochondria and peroxisomes in higher organisms and in the peroxisomes in yeast. The AMP-activated protein kinase regulates this process in mammalian cells, and its homolog Snf1, together with the transcription factors Adr1, Oaf1, and Pip2, regulates peroxisome proliferation and beta-oxidation in yeast. A constitutive allele of Adr1 (Adr1(c)) lacking the glucose- and Snf1-regulated phosphorylation substrate Ser-230 was found to be Snf1-independent for regulation of peroxisomal genes. In addition, it could compensate for and even suppress the requirement for Oaf1 or Pip2 for gene induction. Peroxisomal genes were found to be regulated by oleate in the presence of glucose, as long as Adr1(c) was expressed, suggesting that the Oaf1/Pip2 heterodimer is Snf1-independent. Consistent with this observation, Oaf1 binding to promoters in the presence of oleate was not reduced in a snf1Delta strain. Exploring the mechanism by which Adr1(c) permits Snf1-independent peroxisomal gene induction, we found that strength of promoter binding did not correlate with transcription, suggesting that stable binding is not a prerequisite for enhanced transcription. Instead, enhanced transcriptional activation and suppression of Oaf1, Pip2, and Snf1 by Adr1(c) may be related to the ability of Adr1(c) to suppress the requirement for and enhance the recruitment of transcriptional coactivators in a promoter- and growth medium-dependent manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.