ArticleProceedings of the National Academy of Sciences of the United States of America2010
Arabidopsis IWS1 interacts with transcription factor BES1 and is involved in plant steroid hormone brassinosteroid regulated gene expression.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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61 citing papers in PubMed, 139 citations in OpenAlex.
- The transcription elongation factor IWS1 promotes thermomorphogenesis by integrating the brassinosteroid and gibberellin pathways in Arabidopsis.Plant communications · 2026Article
- Genetic dissection of ten photosynthesis-related traits based on InDel- and SNP-GWAS in soybean.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Chilling stress response in tobacco seedlings: insights from transcriptome, proteome, and phosphoproteome analyses.Frontiers in plant science · 2024Article
- Genome-Wide Characterization and Phylogenetic Analysis of GSK Genes in Maize and Elucidation of Their General Role in Interaction with BZR1.International journal of molecular sciences · 2022Article
- An ortholog of the MADS-box gene SEPALLATA3 regulates stamen development in the woody plant Jatropha curcas.Planta · 2022Article
- Genome-Scale Profiling and High-Throughput Analyses Unravel the Genetic Basis of Arsenic Content Variation in Rice.Frontiers in plant science · 2022Article
- The F-box E3 ubiquitin ligase BAF1 mediates the degradation of the brassinosteroid-activated transcription factor BES1 through selective autophagy in Arabidopsis.The Plant cell · 2021Article
- HBI transcription factor-mediated ROS homeostasis regulates nitrate signal transduction.The Plant cell · 2021Article
- Genome-Wide Identification and Characterization of the Brassinazole-resistant (International journal of molecular sciences · 2021Article
- Transcriptional memories mediate the plasticity of cold stress responses to enable morphological acclimation in Brachypodium distachyon.The New phytologist · 2021Article
- Genome-Wide Prediction, Functional Divergence, and Characterization of Stress-ResponsiveFrontiers in plant science · 2021Article
- Functional Characterization ofInternational journal of molecular sciences · 2020Article
- Article
- A Collection of Pre-mRNA Splicing Mutants inG3 (Bethesda, Md.) · 2020Article
- Genome-Wide Association and Prediction of Traits Related to Salt Tolerance in Autotetraploid Alfalfa (International journal of molecular sciences · 2020Article
- Signalling Overlaps between Nitrate and Auxin in Regulation of The Root System Architecture: Insights from theInternational journal of molecular sciences · 2020Review
- Transcriptome profiling provides insights into molecular mechanism in Peanut semi-dwarf mutant.BMC genomics · 2020Article
- Brassinosteroids: Multidimensional Regulators of Plant Growth, Development, and Stress Responses.The Plant cell · 2020Review
- The AP2/ERF Transcription Factor TINY Modulates Brassinosteroid-Regulated Plant Growth and Drought Responses in Arabidopsis.The Plant cell · 2019Article
- BES/BZR Transcription Factor TaBZR2 Positively Regulates Drought Responses by Activation ofPlant physiology · 2019Article
1 more citing papers are in PubMed but not listed here.
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4 authors at 1 institution in 1 country.
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Abstract
Plant steroid hormones, brassinosteroids (BRs), regulate essential growth and developmental processes. BRs signal through membrane-localized receptor BRI1 and several other signaling components to regulate the BES1 and BZR1 family transcription factors, which in turn control the expression of hundreds of target genes. However, knowledge about the transcriptional mechanisms by which BES1/BZR1 regulate gene expression is limited. By a forward genetic approach, we have discovered that Arabidopsis thaliana Interact-With-Spt6 (AtIWS1), an evolutionarily conserved protein implicated in RNA polymerase II (RNAPII) postrecruitment and transcriptional elongation processes, is required for BR-induced gene expression. Loss-of-function mutations in AtIWS1 lead to overall dwarfism in Arabidopsis, reduced BR response, genome-wide decrease in BR-induced gene expression, and hypersensitivity to a transcription elongation inhibitor. Moreover, AtIWS1 interacts with BES1 both in vitro and in vivo. Chromatin immunoprecipitation experiments demonstrated that the presence of AtIWS1 is enriched in transcribed as well as promoter regions of the target genes under BR-induced conditions. Our results suggest that AtIWS1 is recruited to target genes by BES1 to promote gene expression during transcription elongation process. Recent genomic studies have indicated that a large number of genes could be regulated at steps after RNAPII recruitment; however, the mechanisms for such regulation have not been well established. The study therefore not only establishes an important role for AtIWS1 in plant steroid-induced gene expression but also suggests an exciting possibility that IWS1 protein can function as a target for pathway-specific activators, thereby providing a unique mechanism for the control of gene expression.
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