ArticleJournal of bacteriology2010
Myxococcus xanthus viability depends on groEL supplied by either of two genes, but the paralogs have different functions during heat shock, predation, and development.
Article in Journal of bacteriology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Divergent contributions of multiple PPIases to cell survival, sociality, and stress tolerance inApplied and environmental microbiology · 2026Article
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- DnaK duplication and specialization in bacteria correlates with increased proteome complexity.mSystems · 2024Article
- A Dual-Functional Orphan Response Regulator Negatively Controls the Differential Transcription of DuplicatemSystems · 2022Article
- Development versus predation: Transcriptomic changes during the lifecycle ofFrontiers in microbiology · 2022Article
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- Suppressor mutations reveal an NtrC-like response regulator, NmpR, for modulation of Type-IV Pili-dependent motility in Myxococcus xanthus.PLoS genetics · 2018Article
- Biochemical and Genetic Analysis of the Chlamydia GroEL Chaperonins.Journal of bacteriology · 2017Article
- Article
- Myxobacteria: Moving, Killing, Feeding, and Surviving Together.Frontiers in microbiology · 2016Review
- Transcriptional regulation of the Chlamydia heat shock stress response in an intracellular infection.Molecular microbiology · 2015Article
- Multiple chaperonins in bacteria--novel functions and non-canonical behaviors.Cell stress & chaperones · 2015Review
- The lethal cargo of Myxococcus xanthus outer membrane vesicles.Frontiers in microbiology · 2014Article
- Coevolution analyses illuminate the dependencies between amino acid sites in the chaperonin system GroES-L.BMC evolutionary biology · 2013Article
- Mechanisms involved in the functional divergence of duplicated GroEL chaperonins in Myxococcus xanthus DK1622.PLoS genetics · 2013Article
- Characterization of four type IV pilin homologues in Stigmatella aurantiaca DSM17044 by heterologous expression in Myxococcus xanthus.PloS one · 2013Article
- Extraordinary expansion of a Sorangium cellulosum genome from an alkaline milieu.Scientific reports · 2013Article
- The clpB gene is involved in the stress response of Myxococcus xanthus during vegetative growth and development.Microbiology (Reading, England) · 2012Article
- Mutagenesis of RpoE-like sigma factor genes in Bdellovibrio reveals differential control of groEL and two groES genes.BMC microbiology · 2012Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myxococcus xanthus DK1622 contains two paralogous groEL gene loci that possess both different sequences and different organizations within the genome. Deletion of either one of these two genes alone does not affect cell viability. However, deletion of both groEL genes results in cell death unless a complemented groEL1 or groEL2 gene is present. The groEL1 gene was determined to be essential for cell survival under heat shock conditions; a strain with mutant groEL2 caused cells to be more sensitive than the wild-type strain to higher temperatures. Mutants with a single deletion of either groEL1 (MXAN_4895) or groEL2 (MXAN_4467) had a growth curve similar to that of the wild-type strain DK1622 in medium containing hydrolyzed proteins as the substrate. However, when cells were cultured on medium containing either Escherichia coli cells or casein as the substrate, deletion of groEL2, but not groEL1, led to a deficiency in cell predation and macromolecular feeding. Furthermore, groEL1 was found to play an indispensable role in the development and sporulation of cells, but deletion of groEL2 had no visible effects. Our results suggest that, although alternatively required for cell viability, the products of the two groEL genes have divergent functions in the multicellular social life cycle of M. xanthus DK1622.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.