ArticleThe Journal of biological chemistry2010
Identification of specific lipid-binding sites in integral membrane proteins.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Article
- New insights into the pathogenicity of TMEM165 variants using structural modeling based on AlphaFold 2 predictions.Computational and structural biotechnology journal · 2023Article
- Characterization of Lipid-Protein Interactions and Lipid-Mediated Modulation of Membrane Protein Function through Molecular Simulation.Chemical reviews · 2019Review
- Computational Modeling of Realistic Cell Membranes.Chemical reviews · 2019Review
- Emerging Diversity in Lipid-Protein Interactions.Chemical reviews · 2019Review
- Study of procaine and tetracaine in the lipid bilayer using molecular dynamics simulation.European biophysics journal : EBJ · 2017Article
- Lipid interaction sites on channels, transporters and receptors: Recent insights from molecular dynamics simulations.Biochimica et biophysica acta · 2016Review
- Lipids modulate the conformational dynamics of a secondary multidrug transporter.Nature structural & molecular biology · 2016Article
- Molecular dynamics simulations of the bacterial UraA H+-uracil symporter in lipid bilayers reveal a closed state and a selective interaction with cardiolipin.PLoS computational biology · 2015Article
- Probing the conformation of FhaC with small-angle neutron scattering and molecular modeling.Biophysical journal · 2014Article
- Crosstalk between DnaA protein, the initiator of Escherichia coli chromosomal replication, and acidic phospholipids present in bacterial membranes.International journal of molecular sciences · 2013Review
- Prediction of lipid-binding regions in cytoplasmic and extracellular loops of membrane proteins as exemplified by protein translocation membrane proteins.The Journal of membrane biology · 2013Article
- Lipid recognition propensities of amino acids in membrane proteins from atomic resolution data.BMC biophysics · 2011Article
- Membrane interface composition drives the structure and the tilt of the single transmembrane helix protein PMP1: MD studies.Biophysical journal · 2011Article
- Plasticity of lipid-protein interactions in the function and topogenesis of the membrane protein lactose permease from Escherichia coli.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Lipid composition regulates the orientation of transmembrane helices in HorA, an ABC multidrug transporter.The Journal of biological chemistry · 2010Article
- Role of the Lipid Environment in the Dimerization of Transmembrane Domains of Glycophorin A.Acta naturaeArticle
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein-lipid interactions are increasingly recognized as central to the structure and function of membrane proteins. However, with the exception of simplified models, specific protein-lipid interactions are particularly difficult to highlight experimentally. Here, we used molecular dynamics simulations to identify a specific protein-lipid interaction in lactose permease, a prototypical model for transmembrane proteins. The interactions can be correlated with the functional dependence of the protein to specific lipid species. The technique is simple and widely applicable to other membrane proteins, and a variety of lipid matrices can be used.
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